VARP Is Recruited on to Endosomes by Direct Interaction with Retromer, Where Together They Function in Export to the Cell Surface

VARP Is Recruited on to Endosomes by Direct Interaction with Retromer, Where Together They Function in Export to the Cell Surface

VARP is a Rab32/38 effector that also binds to the endosomal/lysosomal R-SNARE VAMP7. VARP binding regulates VAMP7 participation in SNARE complex formation and can therefore influence VAMP7-mediated membrane fusion events. Mutant versions of VARP that cannot bind Rab32:GTP, designed on the basis of...

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Bibliographic Details
Main Authors: Hesketh, Geoffrey G., Pérez-Dorado, Inmaculada, Jackson, Lauren P., Wartosch, Lena, Schäfer, Ingmar B., Gray, Sally R., McCoy, Airlie J., Zeldin, Oliver B., Garman, Elspeth F., Harbour, Michael E., Evans, Philip R., Seaman, Matthew N.J., Luzio, J. Paul, Owen, David J.
Format: Online
Language:English
Published: Cell Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059916/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059916/

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