A Semi-Synthetic Organism with an Expanded Genetic Alphabet

Organisms are defined by the information encoded in their genomes, and since the evolution of life, this information has been encoded using a two base pair genetic alphabet (A-T and G-C). In vitro, the alphabet has been expanded to include several unnatural base pairs (UBPs)1–3. We have developed a...

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Bibliographic Details
Main Authors: Malyshev, Denis A., Dhami, Kirandeep, Lavergne, Thomas, Chen, Tingjian, Dai, Nan, Foster, Jeremy M., Corrêa, Ivan R., Romesberg, Floyd E.
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058825/