A Systematic Review for Anti-Inflammatory Property of Clusiaceae Family: A Preclinical Approach

Background. Clusiaceae family (sensu lato) is extensively used in ethnomedicine for treating a number of disease conditions which include cancer, inflammation, and infection. The aim of this review is to report the pharmacological potential of plants of Clusiaceae family with the anti-inflammatory...

Full description

Bibliographic Details
Main Authors:	de Melo, Mônica Santos, Quintans, Jullyana de Souza Siqueira, Araújo, Adriano Antunes de Souza, Duarte, Marcelo Cavalcante, Bonjardim, Leonardo Rigoldi, Nogueira, Paulo Cesar de Lima, Moraes, Valéria Regina de Souza, de Araújo-Júnior, João Xavier, Ribeiro, Êurica Adélia Nogueira, Quintans-Júnior, Lucindo José
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058220/

id	pubmed-4058220
recordtype	oai_dc
spelling	pubmed-40582202014-06-29 A Systematic Review for Anti-Inflammatory Property of Clusiaceae Family: A Preclinical Approach de Melo, Mônica Santos Quintans, Jullyana de Souza Siqueira Araújo, Adriano Antunes de Souza Duarte, Marcelo Cavalcante Bonjardim, Leonardo Rigoldi Nogueira, Paulo Cesar de Lima Moraes, Valéria Regina de Souza de Araújo-Júnior, João Xavier Ribeiro, Êurica Adélia Nogueira Quintans-Júnior, Lucindo José Review Article Background. Clusiaceae family (sensu lato) is extensively used in ethnomedicine for treating a number of disease conditions which include cancer, inflammation, and infection. The aim of this review is to report the pharmacological potential of plants of Clusiaceae family with the anti-inflammatory activity in animal experiments. Methods. A systematic review about experiments investigating anti-inflammatory activity of Clusiaceae family was carried out by searching bibliographic databases such as Medline, Scopus and Embase. In this update, the search terms were “anti-inflammatory agents,” “Clusiaceae,” and “animals, laboratory.” Results. A total of 255 publications with plants this family were identified. From the initial 255 studies, a total of 21 studies were selected for the final analysis. Studies with genera Allanblackia, Clusia, Garcinia or Rheedia, and Hypericum showed significant anti-inflammatory activity. The findings include a decrease of total leukocytes, a number of neutrophils, total protein concentration, granuloma formation, and paw or ear edema formation. Other interesting findings included decreased of the MPO activity, and inflammatory mediators such as NF-κB and iNOS expression, PGE2 and Il-1β levels and a decrease in chronic inflammation. Conclusion. The data reported suggests the anti-inflammatory effect potential of Clusiaceae family in animal experiments. Hindawi Publishing Corporation 2014 2014-05-26 /pmc/articles/PMC4058220/ /pubmed/24976853 http://dx.doi.org/10.1155/2014/960258 Text en Copyright © 2014 Mônica Santos de Melo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	de Melo, Mônica Santos Quintans, Jullyana de Souza Siqueira Araújo, Adriano Antunes de Souza Duarte, Marcelo Cavalcante Bonjardim, Leonardo Rigoldi Nogueira, Paulo Cesar de Lima Moraes, Valéria Regina de Souza de Araújo-Júnior, João Xavier Ribeiro, Êurica Adélia Nogueira Quintans-Júnior, Lucindo José
spellingShingle	de Melo, Mônica Santos Quintans, Jullyana de Souza Siqueira Araújo, Adriano Antunes de Souza Duarte, Marcelo Cavalcante Bonjardim, Leonardo Rigoldi Nogueira, Paulo Cesar de Lima Moraes, Valéria Regina de Souza de Araújo-Júnior, João Xavier Ribeiro, Êurica Adélia Nogueira Quintans-Júnior, Lucindo José A Systematic Review for Anti-Inflammatory Property of Clusiaceae Family: A Preclinical Approach
author_facet	de Melo, Mônica Santos Quintans, Jullyana de Souza Siqueira Araújo, Adriano Antunes de Souza Duarte, Marcelo Cavalcante Bonjardim, Leonardo Rigoldi Nogueira, Paulo Cesar de Lima Moraes, Valéria Regina de Souza de Araújo-Júnior, João Xavier Ribeiro, Êurica Adélia Nogueira Quintans-Júnior, Lucindo José
author_sort	de Melo, Mônica Santos
title	A Systematic Review for Anti-Inflammatory Property of Clusiaceae Family: A Preclinical Approach
title_short	A Systematic Review for Anti-Inflammatory Property of Clusiaceae Family: A Preclinical Approach
title_full	A Systematic Review for Anti-Inflammatory Property of Clusiaceae Family: A Preclinical Approach
title_fullStr	A Systematic Review for Anti-Inflammatory Property of Clusiaceae Family: A Preclinical Approach
title_full_unstemmed	A Systematic Review for Anti-Inflammatory Property of Clusiaceae Family: A Preclinical Approach
title_sort	systematic review for anti-inflammatory property of clusiaceae family: a preclinical approach
description	Background. Clusiaceae family (sensu lato) is extensively used in ethnomedicine for treating a number of disease conditions which include cancer, inflammation, and infection. The aim of this review is to report the pharmacological potential of plants of Clusiaceae family with the anti-inflammatory activity in animal experiments. Methods. A systematic review about experiments investigating anti-inflammatory activity of Clusiaceae family was carried out by searching bibliographic databases such as Medline, Scopus and Embase. In this update, the search terms were “anti-inflammatory agents,” “Clusiaceae,” and “animals, laboratory.” Results. A total of 255 publications with plants this family were identified. From the initial 255 studies, a total of 21 studies were selected for the final analysis. Studies with genera Allanblackia, Clusia, Garcinia or Rheedia, and Hypericum showed significant anti-inflammatory activity. The findings include a decrease of total leukocytes, a number of neutrophils, total protein concentration, granuloma formation, and paw or ear edema formation. Other interesting findings included decreased of the MPO activity, and inflammatory mediators such as NF-κB and iNOS expression, PGE2 and Il-1β levels and a decrease in chronic inflammation. Conclusion. The data reported suggests the anti-inflammatory effect potential of Clusiaceae family in animal experiments.
publisher	Hindawi Publishing Corporation
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058220/
_version_	1612101619510411264

A Systematic Review for Anti-Inflammatory Property of Clusiaceae Family: A Preclinical Approach

Similar Items