Glutamine supplementation in the critically ill: friend or foe?
In the previous issue of Critical Care, Mori and colleagues demonstrate that glutamine supplementation in mechanically ventilated patients as part of parenteral nutrition increases plasma glutamine concentration and glutamine utilization, but does not mitigate protein degradation and even increases...
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BioMed Central
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056981/ |
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pubmed-4056981 |
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pubmed-40569812015-05-19 Glutamine supplementation in the critically ill: friend or foe? Oudemans-van Straaten, Heleen M van Zanten, Arthur RH Commentary In the previous issue of Critical Care, Mori and colleagues demonstrate that glutamine supplementation in mechanically ventilated patients as part of parenteral nutrition increases plasma glutamine concentration and glutamine utilization, but does not mitigate protein degradation and even increases de novo glutamine production. Studies suggest that protein degradation is regulated by the degree of inflammation. Immune cells utilize large amounts of glutamine and derive their glutamine requirements from muscle protein degradation. We hypothesize that the effects of glutamine supplementation depend on the degree of inflammation. Infusing large amounts of exogenous glutamine into patients with inflammatory conditions like sepsis and multiple organ failure may not only enhance immune competence, but may potentially augment the inflammatory response and thereby negatively influence outcome. BioMed Central 2014 2014-05-19 /pmc/articles/PMC4056981/ /pubmed/25032515 http://dx.doi.org/10.1186/cc13879 Text en Copyright © 2014 Oudemans-van Straaten and Van Zanten; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 The licensee has exclusive rights to distribute this article, in any medium, for 12 months following its publication. After this time, the article is available under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Oudemans-van Straaten, Heleen M van Zanten, Arthur RH |
| spellingShingle |
Oudemans-van Straaten, Heleen M van Zanten, Arthur RH Glutamine supplementation in the critically ill: friend or foe? |
| author_facet |
Oudemans-van Straaten, Heleen M van Zanten, Arthur RH |
| author_sort |
Oudemans-van Straaten, Heleen M |
| title |
Glutamine supplementation in the critically ill: friend or foe? |
| title_short |
Glutamine supplementation in the critically ill: friend or foe? |
| title_full |
Glutamine supplementation in the critically ill: friend or foe? |
| title_fullStr |
Glutamine supplementation in the critically ill: friend or foe? |
| title_full_unstemmed |
Glutamine supplementation in the critically ill: friend or foe? |
| title_sort |
glutamine supplementation in the critically ill: friend or foe? |
| description |
In the previous issue of Critical Care, Mori and colleagues demonstrate that glutamine supplementation in mechanically ventilated patients as part of parenteral nutrition increases plasma glutamine concentration and glutamine utilization, but does not mitigate protein degradation and even increases de novo glutamine production. Studies suggest that protein degradation is regulated by the degree of inflammation. Immune cells utilize large amounts of glutamine and derive their glutamine requirements from muscle protein degradation. We hypothesize that the effects of glutamine supplementation depend on the degree of inflammation. Infusing large amounts of exogenous glutamine into patients with inflammatory conditions like sepsis and multiple organ failure may not only enhance immune competence, but may potentially augment the inflammatory response and thereby negatively influence outcome. |
| publisher |
BioMed Central |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056981/ |
| _version_ |
1612101028582260736 |