Inhibition of the Polyamine System Counteracts β-Amyloid Peptide-Induced Memory Impairment in Mice: Involvement of Extrasynaptic NMDA Receptors

Inhibition of the Polyamine System Counteracts β-Amyloid Peptide-Induced Memory Impairment in Mice: Involvement of Extrasynaptic NMDA Receptors

In Alzheimer's disease (AD), the β-amyloid peptide (Aβ) has been causally linked to synaptic dysfunction and cognitive impairment. Several studies have shown that N-Methyl-D-Aspartate receptors (NMDAR) activation is involved in the detrimental actions of Aβ. Polyamines, like spermidine and sper...

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Bibliographic Details
Main Authors: Gomes, Guilherme Monteiro, Dalmolin, Gerusa Duarte, Bär, Julia, Karpova, Anna, Mello, Carlos Fernando, Kreutz, Michael R., Rubin, Maribel Antonello
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055672/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055672/

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