A computational framework for boosting confidence in high-throughput protein-protein interaction datasets

Improving the quality and coverage of the protein interactome is of tantamount importance for biomedical research, particularly given the various sources of uncertainty in high-throughput techniques. We introduce a structure-based framework, Coev2Net, for computing a single confidence score that add...

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Bibliographic Details
Main Authors: Hosur, Raghavendra, Peng, Jian, Vinayagam, Arunachalam, Stelzl, Ulrich, Xu, Jinbo, Perrimon, Norbert, Bienkowska, Jadwiga, Berger, Bonnie
Format: Online
Language:English
Published: BioMed Central 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053744/