The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer's Disease: A Systematic Review

Purpose. Oxidative stress plays an important role in the pathogenesis of Alzheimer's disease (AD). This paper aims to examine whether biomarkers of oxidative stress and antioxidants could be useful biomarkers in AD, which might form the bases of future clinical studies. Methods. PubMed, SCOPUS...

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Main Authors:	Chang, Ya-Ting, Chang, Wen-Neng, Tsai, Nai-Wen, Huang, Chih-Cheng, Kung, Chia-Te, Su, Yu-Jih, Lin, Wei-Che, Cheng, Ben-Chung, Su, Chih-Min, Chiang, Yi-Fang, Lu, Cheng-Hsien
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053273/

id	pubmed-4053273
recordtype	oai_dc
spelling	pubmed-40532732014-06-19 The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer's Disease: A Systematic Review Chang, Ya-Ting Chang, Wen-Neng Tsai, Nai-Wen Huang, Chih-Cheng Kung, Chia-Te Su, Yu-Jih Lin, Wei-Che Cheng, Ben-Chung Su, Chih-Min Chiang, Yi-Fang Lu, Cheng-Hsien Review Article Purpose. Oxidative stress plays an important role in the pathogenesis of Alzheimer's disease (AD). This paper aims to examine whether biomarkers of oxidative stress and antioxidants could be useful biomarkers in AD, which might form the bases of future clinical studies. Methods. PubMed, SCOPUS, and Web of Science were systematically queried to obtain studies with available data regarding markers of oxidative stress and antioxidants from subjects with AD. Results and Conclusion. Although most studies show elevated serum markers of lipid peroxidation in AD, there is no sufficient evidence to justify the routine use of biomarkers as predictors of severity or outcome in AD. Hindawi Publishing Corporation 2014 2014-05-14 /pmc/articles/PMC4053273/ /pubmed/24949424 http://dx.doi.org/10.1155/2014/182303 Text en Copyright © 2014 Ya-Ting Chang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Chang, Ya-Ting Chang, Wen-Neng Tsai, Nai-Wen Huang, Chih-Cheng Kung, Chia-Te Su, Yu-Jih Lin, Wei-Che Cheng, Ben-Chung Su, Chih-Min Chiang, Yi-Fang Lu, Cheng-Hsien
spellingShingle	Chang, Ya-Ting Chang, Wen-Neng Tsai, Nai-Wen Huang, Chih-Cheng Kung, Chia-Te Su, Yu-Jih Lin, Wei-Che Cheng, Ben-Chung Su, Chih-Min Chiang, Yi-Fang Lu, Cheng-Hsien The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer's Disease: A Systematic Review
author_facet	Chang, Ya-Ting Chang, Wen-Neng Tsai, Nai-Wen Huang, Chih-Cheng Kung, Chia-Te Su, Yu-Jih Lin, Wei-Che Cheng, Ben-Chung Su, Chih-Min Chiang, Yi-Fang Lu, Cheng-Hsien
author_sort	Chang, Ya-Ting
title	The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer's Disease: A Systematic Review
title_short	The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer's Disease: A Systematic Review
title_full	The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer's Disease: A Systematic Review
title_fullStr	The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer's Disease: A Systematic Review
title_full_unstemmed	The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer's Disease: A Systematic Review
title_sort	roles of biomarkers of oxidative stress and antioxidant in alzheimer's disease: a systematic review
description	Purpose. Oxidative stress plays an important role in the pathogenesis of Alzheimer's disease (AD). This paper aims to examine whether biomarkers of oxidative stress and antioxidants could be useful biomarkers in AD, which might form the bases of future clinical studies. Methods. PubMed, SCOPUS, and Web of Science were systematically queried to obtain studies with available data regarding markers of oxidative stress and antioxidants from subjects with AD. Results and Conclusion. Although most studies show elevated serum markers of lipid peroxidation in AD, there is no sufficient evidence to justify the routine use of biomarkers as predictors of severity or outcome in AD.
publisher	Hindawi Publishing Corporation
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053273/
_version_	1612099593767485440

The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer's Disease: A Systematic Review

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