The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease

The chemokine receptor CXCR4 and its ligand CXCL12 play an important homeostatic function by mediating the homing of progenitor cells in the bone marrow and regulating their mobilization into peripheral tissues upon injury or stress. Although the CXCL12/CXCR4 interaction has long been regarded as a...

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Main Authors:	Döring, Yvonne, Pawig, Lukas, Weber, Christian, Noels, Heidi
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052746/

id	pubmed-4052746
recordtype	oai_dc
spelling	pubmed-40527462014-06-25 The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease Döring, Yvonne Pawig, Lukas Weber, Christian Noels, Heidi Physiology The chemokine receptor CXCR4 and its ligand CXCL12 play an important homeostatic function by mediating the homing of progenitor cells in the bone marrow and regulating their mobilization into peripheral tissues upon injury or stress. Although the CXCL12/CXCR4 interaction has long been regarded as a monogamous relation, the identification of the pro-inflammatory chemokine macrophage migration inhibitory factor (MIF) as an important second ligand for CXCR4, and of CXCR7 as an alternative receptor for CXCL12, has undermined this interpretation and has considerably complicated the understanding of CXCL12/CXCR4 signaling and associated biological functions. This review aims to provide insight into the current concept of the CXCL12/CXCR4 axis in myocardial infarction (MI) and its underlying pathologies such as atherosclerosis and injury-induced vascular restenosis. It will discuss main findings from in vitro studies, animal experiments and large-scale genome-wide association studies. The importance of the CXCL12/CXCR4 axis in progenitor cell homing and mobilization will be addressed, as will be the function of CXCR4 in different cell types involved in atherosclerosis. Finally, a potential translation of current knowledge on CXCR4 into future therapeutical application will be discussed. Frontiers Media S.A. 2014-06-11 /pmc/articles/PMC4052746/ /pubmed/24966838 http://dx.doi.org/10.3389/fphys.2014.00212 Text en Copyright © 2014 Döring, Pawig, Weber and Noels. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Döring, Yvonne Pawig, Lukas Weber, Christian Noels, Heidi
spellingShingle	Döring, Yvonne Pawig, Lukas Weber, Christian Noels, Heidi The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease
author_facet	Döring, Yvonne Pawig, Lukas Weber, Christian Noels, Heidi
author_sort	Döring, Yvonne
title	The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease
title_short	The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease
title_full	The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease
title_fullStr	The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease
title_full_unstemmed	The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease
title_sort	cxcl12/cxcr4 chemokine ligand/receptor axis in cardiovascular disease
description	The chemokine receptor CXCR4 and its ligand CXCL12 play an important homeostatic function by mediating the homing of progenitor cells in the bone marrow and regulating their mobilization into peripheral tissues upon injury or stress. Although the CXCL12/CXCR4 interaction has long been regarded as a monogamous relation, the identification of the pro-inflammatory chemokine macrophage migration inhibitory factor (MIF) as an important second ligand for CXCR4, and of CXCR7 as an alternative receptor for CXCL12, has undermined this interpretation and has considerably complicated the understanding of CXCL12/CXCR4 signaling and associated biological functions. This review aims to provide insight into the current concept of the CXCL12/CXCR4 axis in myocardial infarction (MI) and its underlying pathologies such as atherosclerosis and injury-induced vascular restenosis. It will discuss main findings from in vitro studies, animal experiments and large-scale genome-wide association studies. The importance of the CXCL12/CXCR4 axis in progenitor cell homing and mobilization will be addressed, as will be the function of CXCR4 in different cell types involved in atherosclerosis. Finally, a potential translation of current knowledge on CXCR4 into future therapeutical application will be discussed.
publisher	Frontiers Media S.A.
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052746/
_version_	1612099432472379392

The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease

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