Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

The insulin/IGF-1 (insulin-like growth factor 1)-activated protein kinase Akt (also known as protein kinase B) phosphorylates Ser487 in the ‘ST loop’ (serine/threonine-rich loop) within the C-terminal domain of AMPK-α1 (AMP-activated protein kinase-α1), leading to inhibition of phosphorylation by up...

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Bibliographic Details
Main Authors: Hawley, Simon A., Ross, Fiona A., Gowans, Graeme J., Tibarewal, Priyanka, Leslie, Nicholas R., Hardie, D. Grahame
Format: Online
Language:English
Published: Portland Press Ltd. 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052680/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052680/

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