Gla-Rich Protein Is a Potential New Vitamin K Target in Cancer: Evidences for a Direct GRP-Mineral Interaction

Gla-rich protein (GRP) was described in sturgeon as a new vitamin-K-dependent protein (VKDP) with a high density of Gla residues and associated with ectopic calcifications in humans. Although VKDPs function has been related with γ-carboxylation, the Gla status of GRP in humans is still unknown. Here...

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Bibliographic Details
Main Authors: Viegas, Carla S. B., Herfs, Marjolein, Rafael, Marta S., Enriquez, José L., Teixeira, Alexandra, Luís, Inês M., van ‘t Hoofd, Cynthia M. R., João, Alexandre, Maria, Vera L., Cavaco, Sofia, Ferreira, Ana, Serra, Manuel, Theuwissen, Elke, Vermeer, Cees, Simes, Dina C.
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052551/