tRNAs as regulators of biological processes
Transfer RNAs (tRNA) are best known for their role as adaptors during translation of the genetic code. Beyond their canonical role during protein biosynthesis, tRNAs also perform additional functions in both prokaryotes and eukaryotes for example in regulating gene expression. Aminoacylated tRNAs ha...
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| Format: | Online |
| Language: | English |
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Frontiers Media S.A.
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052509/ |
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pubmed-40525092014-06-25 tRNAs as regulators of biological processes Raina, Medha Ibba, Michael Genetics Transfer RNAs (tRNA) are best known for their role as adaptors during translation of the genetic code. Beyond their canonical role during protein biosynthesis, tRNAs also perform additional functions in both prokaryotes and eukaryotes for example in regulating gene expression. Aminoacylated tRNAs have also been implicated as substrates for non-ribosomal peptide bond formation, post-translational protein labeling, modification of phospholipids in the cell membrane, and antibiotic biosyntheses. Most recently tRNA fragments, or tRFs, have also been recognized to play regulatory roles. Here, we examine in more detail some of the new functions emerging for tRNA in a variety of cellular processes outside of protein synthesis. Frontiers Media S.A. 2014-06-11 /pmc/articles/PMC4052509/ /pubmed/24966867 http://dx.doi.org/10.3389/fgene.2014.00171 Text en Copyright © 2014 Raina and Ibba. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Raina, Medha Ibba, Michael |
| spellingShingle |
Raina, Medha Ibba, Michael tRNAs as regulators of biological processes |
| author_facet |
Raina, Medha Ibba, Michael |
| author_sort |
Raina, Medha |
| title |
tRNAs as regulators of biological processes |
| title_short |
tRNAs as regulators of biological processes |
| title_full |
tRNAs as regulators of biological processes |
| title_fullStr |
tRNAs as regulators of biological processes |
| title_full_unstemmed |
tRNAs as regulators of biological processes |
| title_sort |
trnas as regulators of biological processes |
| description |
Transfer RNAs (tRNA) are best known for their role as adaptors during translation of the genetic code. Beyond their canonical role during protein biosynthesis, tRNAs also perform additional functions in both prokaryotes and eukaryotes for example in regulating gene expression. Aminoacylated tRNAs have also been implicated as substrates for non-ribosomal peptide bond formation, post-translational protein labeling, modification of phospholipids in the cell membrane, and antibiotic biosyntheses. Most recently tRNA fragments, or tRFs, have also been recognized to play regulatory roles. Here, we examine in more detail some of the new functions emerging for tRNA in a variety of cellular processes outside of protein synthesis. |
| publisher |
Frontiers Media S.A. |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052509/ |
| _version_ |
1612099336499363840 |