The Genetic and Biochemical Basis of FANCD2 Monoubiquitination
Fanconi anaemia (FA) is a cancer predisposition syndrome characterized by cellular sensitivity to DNA interstrand crosslinkers. The molecular defect in FA is an impaired DNA repair pathway. The critical event in activating this pathway is monoubiquitination of FANCD2. In vivo, a multisubunit FA core...
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Cell Press
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051986/ |