How and where are nonsense mRNAs degraded in mammalian cells?
The nonsense-mediated mRNA decay (NMD) pathway is responsible for the rapid degradation of eukaryotic mRNAs on which ribosomes fail to terminate translation properly. NMD thereby contributes to the elimination of aberrant mRNAs, improving the fidelity of gene expression, but also serves to regulate...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
Landes Bioscience
2010
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049745/ |