Insensible Is a Novel Nuclear Inhibitor of Notch Activity in Drosophila
Notch signalling regulates a wide range of developmental processes. In the Drosophila peripheral nervous system, Notch regulates a series of binary fate decisions that lead to the formation of regularly spaced sensory organs. Each sensory organ is generated by single sensory organ precursor cell (SO...
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| Format: | Online |
| Language: | English |
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Public Library of Science
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046977/ |
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pubmed-4046977 |
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pubmed-40469772014-06-09 Insensible Is a Novel Nuclear Inhibitor of Notch Activity in Drosophila Coumailleau, Franck Schweisguth, François Research Article Notch signalling regulates a wide range of developmental processes. In the Drosophila peripheral nervous system, Notch regulates a series of binary fate decisions that lead to the formation of regularly spaced sensory organs. Each sensory organ is generated by single sensory organ precursor cell (SOP) via a series of asymmetric cell divisions. Starting from a SOP-specific Cis-Regulatory Module (CRM), we identified insensible (insb), a.k.a CG6520, as a SOP/neuron-specific gene encoding a nuclear factor that inhibits Notch signalling activity. First, over-expression of Insb led to the transcriptional repression of a Notch reporter and to phenotypes associated with the inhibition of Notch. Second, while the complete loss of insb activity had no significant phenotype, it enhanced the bristle phenotype associated with reduced levels of Hairless, a nuclear protein acting as a co-repressor for Suppressor of Hairless. In conclusion, our work identified Insb as a novel SOP/neuron-specific nuclear inhibitor of Notch activity in Drosophila. Public Library of Science 2014-06-05 /pmc/articles/PMC4046977/ /pubmed/24902027 http://dx.doi.org/10.1371/journal.pone.0098213 Text en © 2014 Coumailleau, Schweisguth http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Coumailleau, Franck Schweisguth, François |
| spellingShingle |
Coumailleau, Franck Schweisguth, François Insensible Is a Novel Nuclear Inhibitor of Notch Activity in Drosophila |
| author_facet |
Coumailleau, Franck Schweisguth, François |
| author_sort |
Coumailleau, Franck |
| title |
Insensible Is a Novel Nuclear Inhibitor of Notch Activity in Drosophila
|
| title_short |
Insensible Is a Novel Nuclear Inhibitor of Notch Activity in Drosophila
|
| title_full |
Insensible Is a Novel Nuclear Inhibitor of Notch Activity in Drosophila
|
| title_fullStr |
Insensible Is a Novel Nuclear Inhibitor of Notch Activity in Drosophila
|
| title_full_unstemmed |
Insensible Is a Novel Nuclear Inhibitor of Notch Activity in Drosophila
|
| title_sort |
insensible is a novel nuclear inhibitor of notch activity in drosophila |
| description |
Notch signalling regulates a wide range of developmental processes. In the Drosophila peripheral nervous system, Notch regulates a series of binary fate decisions that lead to the formation of regularly spaced sensory organs. Each sensory organ is generated by single sensory organ precursor cell (SOP) via a series of asymmetric cell divisions. Starting from a SOP-specific Cis-Regulatory Module (CRM), we identified insensible (insb), a.k.a CG6520, as a SOP/neuron-specific gene encoding a nuclear factor that inhibits Notch signalling activity. First, over-expression of Insb led to the transcriptional repression of a Notch reporter and to phenotypes associated with the inhibition of Notch. Second, while the complete loss of insb activity had no significant phenotype, it enhanced the bristle phenotype associated with reduced levels of Hairless, a nuclear protein acting as a co-repressor for Suppressor of Hairless. In conclusion, our work identified Insb as a novel SOP/neuron-specific nuclear inhibitor of Notch activity in Drosophila. |
| publisher |
Public Library of Science |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046977/ |
| _version_ |
1612097488692445184 |