Binocular Integration in the Mouse Lateral Geniculate Nuclei
A key task for the visual system is to combine spatially overlapping representations of the environment, viewed by either eye, into a coherent image. In cats and primates, this is accomplished in the cortex [1], with retinal outputs maintained as separate monocular maps en route through the lateral...
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| Format: | Online |
| Language: | English |
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Cell Press
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046226/ |
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pubmed-4046226 |
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pubmed-40462262014-06-06 Binocular Integration in the Mouse Lateral Geniculate Nuclei Howarth, Michael Walmsley, Lauren Brown, Timothy M. Report A key task for the visual system is to combine spatially overlapping representations of the environment, viewed by either eye, into a coherent image. In cats and primates, this is accomplished in the cortex [1], with retinal outputs maintained as separate monocular maps en route through the lateral geniculate nucleus (LGN). While this arrangement is also believed to apply to rodents [2, 3], this has not been functionally confirmed. Accordingly, here we used multielectrode recordings to survey eye-specific visual responses across the mouse LGN. Surprisingly, while we find that regions of space visible to both eyes do indeed form part of a monocular representation of the contralateral visual field, we find no evidence for a corresponding ipsilateral representation. Instead, we find many cells that can be driven via either eye. These inputs combine to enhance the detection of weak stimuli, forming a binocular representation of frontal visual space. This extensive thalamic integration marks a fundamental distinction in mechanisms of binocular processing between mice and other mammals. Cell Press 2014-06-02 /pmc/articles/PMC4046226/ /pubmed/24856206 http://dx.doi.org/10.1016/j.cub.2014.04.014 Text en © 2014 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Howarth, Michael Walmsley, Lauren Brown, Timothy M. |
| spellingShingle |
Howarth, Michael Walmsley, Lauren Brown, Timothy M. Binocular Integration in the Mouse Lateral Geniculate Nuclei |
| author_facet |
Howarth, Michael Walmsley, Lauren Brown, Timothy M. |
| author_sort |
Howarth, Michael |
| title |
Binocular Integration in the Mouse Lateral Geniculate Nuclei |
| title_short |
Binocular Integration in the Mouse Lateral Geniculate Nuclei |
| title_full |
Binocular Integration in the Mouse Lateral Geniculate Nuclei |
| title_fullStr |
Binocular Integration in the Mouse Lateral Geniculate Nuclei |
| title_full_unstemmed |
Binocular Integration in the Mouse Lateral Geniculate Nuclei |
| title_sort |
binocular integration in the mouse lateral geniculate nuclei |
| description |
A key task for the visual system is to combine spatially overlapping representations of the environment, viewed by either eye, into a coherent image. In cats and primates, this is accomplished in the cortex [1], with retinal outputs maintained as separate monocular maps en route through the lateral geniculate nucleus (LGN). While this arrangement is also believed to apply to rodents [2, 3], this has not been functionally confirmed. Accordingly, here we used multielectrode recordings to survey eye-specific visual responses across the mouse LGN. Surprisingly, while we find that regions of space visible to both eyes do indeed form part of a monocular representation of the contralateral visual field, we find no evidence for a corresponding ipsilateral representation. Instead, we find many cells that can be driven via either eye. These inputs combine to enhance the detection of weak stimuli, forming a binocular representation of frontal visual space. This extensive thalamic integration marks a fundamental distinction in mechanisms of binocular processing between mice and other mammals. |
| publisher |
Cell Press |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046226/ |
| _version_ |
1612097264292986880 |