Pneumococcal Serotypes and Serogroups Causing Invasive Disease in Pakistan, 2005–2013
While pneumococcal conjugate vaccines have been implemented in most countries worldwide, use in Asia has lagged in part because of a lack of data on the amount of disease that is vaccine preventable in the region. We describe pneumococcal serotypes elicited from 111 episodes of invasive pneumococcal...
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Public Library of Science
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043782/ |
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pubmed-40437822014-06-09 Pneumococcal Serotypes and Serogroups Causing Invasive Disease in Pakistan, 2005–2013 Shakoor, Sadia Kabir, Furqan Khowaja, Asif R. Qureshi, Shahida M. Jehan, Fyezah Qamar, Farah Whitney, Cynthia G. Zaidi, Anita K. M. Research Article While pneumococcal conjugate vaccines have been implemented in most countries worldwide, use in Asia has lagged in part because of a lack of data on the amount of disease that is vaccine preventable in the region. We describe pneumococcal serotypes elicited from 111 episodes of invasive pneumococcal disease (IPD) from 2005 to 2013 among children and adults in Pakistan. Seventy-three percent (n = 81) of 111 IPD episodes were cases of meningitis (n = 76 in children 0–15 years and n = 5 among adults). Serotypes were determined by target amplification of DNA extracted from pneumococcal isolates (n = 52) or CSF specimens (n = 59). Serogroup 18 was the most common serogroup causing meningitis in children <5 years, accounting for 21% of cases (n = 13). The 10-valent pneumococcal conjugate vaccine (PCV 10) or PCV10- related serotypes were found in 61% (n = 47) of childhood (age 0–15 years) meningitis episodes. PCV-13 increased this coverage to 63% (one additional serotype 19A; n = 48). Our data indicate that use of PCVs would prevent a large proportion of serious pneumococcal disease. Public Library of Science 2014-06-03 /pmc/articles/PMC4043782/ /pubmed/24892937 http://dx.doi.org/10.1371/journal.pone.0098796 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Shakoor, Sadia Kabir, Furqan Khowaja, Asif R. Qureshi, Shahida M. Jehan, Fyezah Qamar, Farah Whitney, Cynthia G. Zaidi, Anita K. M. |
| spellingShingle |
Shakoor, Sadia Kabir, Furqan Khowaja, Asif R. Qureshi, Shahida M. Jehan, Fyezah Qamar, Farah Whitney, Cynthia G. Zaidi, Anita K. M. Pneumococcal Serotypes and Serogroups Causing Invasive Disease in Pakistan, 2005–2013 |
| author_facet |
Shakoor, Sadia Kabir, Furqan Khowaja, Asif R. Qureshi, Shahida M. Jehan, Fyezah Qamar, Farah Whitney, Cynthia G. Zaidi, Anita K. M. |
| author_sort |
Shakoor, Sadia |
| title |
Pneumococcal Serotypes and Serogroups Causing Invasive Disease in Pakistan, 2005–2013 |
| title_short |
Pneumococcal Serotypes and Serogroups Causing Invasive Disease in Pakistan, 2005–2013 |
| title_full |
Pneumococcal Serotypes and Serogroups Causing Invasive Disease in Pakistan, 2005–2013 |
| title_fullStr |
Pneumococcal Serotypes and Serogroups Causing Invasive Disease in Pakistan, 2005–2013 |
| title_full_unstemmed |
Pneumococcal Serotypes and Serogroups Causing Invasive Disease in Pakistan, 2005–2013 |
| title_sort |
pneumococcal serotypes and serogroups causing invasive disease in pakistan, 2005–2013 |
| description |
While pneumococcal conjugate vaccines have been implemented in most countries worldwide, use in Asia has lagged in part because of a lack of data on the amount of disease that is vaccine preventable in the region. We describe pneumococcal serotypes elicited from 111 episodes of invasive pneumococcal disease (IPD) from 2005 to 2013 among children and adults in Pakistan. Seventy-three percent (n = 81) of 111 IPD episodes were cases of meningitis (n = 76 in children 0–15 years and n = 5 among adults). Serotypes were determined by target amplification of DNA extracted from pneumococcal isolates (n = 52) or CSF specimens (n = 59). Serogroup 18 was the most common serogroup causing meningitis in children <5 years, accounting for 21% of cases (n = 13). The 10-valent pneumococcal conjugate vaccine (PCV 10) or PCV10- related serotypes were found in 61% (n = 47) of childhood (age 0–15 years) meningitis episodes. PCV-13 increased this coverage to 63% (one additional serotype 19A; n = 48). Our data indicate that use of PCVs would prevent a large proportion of serious pneumococcal disease. |
| publisher |
Public Library of Science |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043782/ |
| _version_ |
1612096119733485568 |