Diffusion Tensor Imaging Study of White Matter Damage in Chronic Meningitis

Diffusion Tensor Imaging Study of White Matter Damage in Chronic Meningitis

Tuberculous meningitis (TBM) and cryptococcal meningitis (CM) are two of the most common types of chronic meningitis. This study aimed to assess whether chronic neuro-psychological sequelae are associated with micro-structure white matter (WM) damage in HIV-negative chronic meningitis. Nineteen HIV-...

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Main Authors: Lin, Wei-Che, Chen, Pei-Chin, Wang, Hung-Chen, Tsai, Nai-Wen, Chou, Kun-Hsien, Chen, Hsiu-Ling, Su, Yu-Jih, Lin, Ching-Po, Li, Shau-Hsuan, Chang, Wen-Neng, Lu, Cheng-Hsien
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043527/
id pubmed-4043527
recordtype oai_dc
spelling pubmed-40435272014-06-09 Diffusion Tensor Imaging Study of White Matter Damage in Chronic Meningitis Lin, Wei-Che Chen, Pei-Chin Wang, Hung-Chen Tsai, Nai-Wen Chou, Kun-Hsien Chen, Hsiu-Ling Su, Yu-Jih Lin, Ching-Po Li, Shau-Hsuan Chang, Wen-Neng Lu, Cheng-Hsien Research Article Tuberculous meningitis (TBM) and cryptococcal meningitis (CM) are two of the most common types of chronic meningitis. This study aimed to assess whether chronic neuro-psychological sequelae are associated with micro-structure white matter (WM) damage in HIV-negative chronic meningitis. Nineteen HIV-negative TBM patients, 13 HIV-negative CM patients, and 32 sex- and age-matched healthy volunteers were evaluated and compared. The clinical relevance of WM integrity was studied using voxel-based diffusion tensor imaging (DTI) magnetic resonance imaging. All of the participants underwent complete medical and neurologic examinations, and neuro-psychological testing. Differences in DTI indices correlated with the presence of neuro-psychological rating scores and cerebrospinal fluid (CSF) analysis during the initial hospitalization. Patients with CM had more severe cognitive deficits than healthy subjects, especially in TBM. There were changes in WM integrity in several limbic regions, including the para-hippocampal gyrus and cingulate gyrus, and in the WM close to the globus pallidus. A decline in WM integrity close to the globus pallidus and anterior cingulate gyrus was associated with worse CSF analysis profiles. Poorer DTI parameters directly correlated with worse cognitive performance on follow-up. These correlations suggest that WM alterations may be involved in the psychopathology and pathophysiology of co-morbidities. Abnormalities in the limbic system and globus pallidus, with their close relationship to the CSF space, may be specific biomarkers for disease evaluation. Public Library of Science 2014-06-03 /pmc/articles/PMC4043527/ /pubmed/24892826 http://dx.doi.org/10.1371/journal.pone.0098210 Text en © 2014 Lin et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Lin, Wei-Che
Chen, Pei-Chin
Wang, Hung-Chen
Tsai, Nai-Wen
Chou, Kun-Hsien
Chen, Hsiu-Ling
Su, Yu-Jih
Lin, Ching-Po
Li, Shau-Hsuan
Chang, Wen-Neng
Lu, Cheng-Hsien
spellingShingle Lin, Wei-Che
Chen, Pei-Chin
Wang, Hung-Chen
Tsai, Nai-Wen
Chou, Kun-Hsien
Chen, Hsiu-Ling
Su, Yu-Jih
Lin, Ching-Po
Li, Shau-Hsuan
Chang, Wen-Neng
Lu, Cheng-Hsien
Diffusion Tensor Imaging Study of White Matter Damage in Chronic Meningitis
author_facet Lin, Wei-Che
Chen, Pei-Chin
Wang, Hung-Chen
Tsai, Nai-Wen
Chou, Kun-Hsien
Chen, Hsiu-Ling
Su, Yu-Jih
Lin, Ching-Po
Li, Shau-Hsuan
Chang, Wen-Neng
Lu, Cheng-Hsien
author_sort Lin, Wei-Che
title Diffusion Tensor Imaging Study of White Matter Damage in Chronic Meningitis
title_short Diffusion Tensor Imaging Study of White Matter Damage in Chronic Meningitis
title_full Diffusion Tensor Imaging Study of White Matter Damage in Chronic Meningitis
title_fullStr Diffusion Tensor Imaging Study of White Matter Damage in Chronic Meningitis
title_full_unstemmed Diffusion Tensor Imaging Study of White Matter Damage in Chronic Meningitis
title_sort diffusion tensor imaging study of white matter damage in chronic meningitis
description Tuberculous meningitis (TBM) and cryptococcal meningitis (CM) are two of the most common types of chronic meningitis. This study aimed to assess whether chronic neuro-psychological sequelae are associated with micro-structure white matter (WM) damage in HIV-negative chronic meningitis. Nineteen HIV-negative TBM patients, 13 HIV-negative CM patients, and 32 sex- and age-matched healthy volunteers were evaluated and compared. The clinical relevance of WM integrity was studied using voxel-based diffusion tensor imaging (DTI) magnetic resonance imaging. All of the participants underwent complete medical and neurologic examinations, and neuro-psychological testing. Differences in DTI indices correlated with the presence of neuro-psychological rating scores and cerebrospinal fluid (CSF) analysis during the initial hospitalization. Patients with CM had more severe cognitive deficits than healthy subjects, especially in TBM. There were changes in WM integrity in several limbic regions, including the para-hippocampal gyrus and cingulate gyrus, and in the WM close to the globus pallidus. A decline in WM integrity close to the globus pallidus and anterior cingulate gyrus was associated with worse CSF analysis profiles. Poorer DTI parameters directly correlated with worse cognitive performance on follow-up. These correlations suggest that WM alterations may be involved in the psychopathology and pathophysiology of co-morbidities. Abnormalities in the limbic system and globus pallidus, with their close relationship to the CSF space, may be specific biomarkers for disease evaluation.
publisher Public Library of Science
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043527/
_version_ 1612095973499076608

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