Identification of 2R-ohnologue gene families displaying the same mutation-load skew in multiple cancers
The complexity of signalling pathways was boosted at the origin of the vertebrates, when two rounds of whole genome duplication (2R-WGD) occurred. Those genes and proteins that have survived from the 2R-WGD—termed 2R-ohnologues—belong to families of two to four members, and are enriched in signallin...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Royal Society
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042849/ |