Dendritic Cells Utilize the Evolutionarily Conserved WASH and Retromer Complexes to Promote MHCII Recycling and Helper T Cell Priming

Dendritic Cells Utilize the Evolutionarily Conserved WASH and Retromer Complexes to Promote MHCII Recycling and Helper T Cell Priming

Immature dendritic cells (DCs) maintain a highly dynamic pool of recycling MHCII that promotes sampling of environmental antigens for presentation to T helper cells. However, the molecular basis of MHCII recycling and the cellular machinery that orchestrates MHCII trafficking are incompletely unders...

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Bibliographic Details
Main Authors: Graham, Daniel B., Osborne, Douglas G., Piotrowski, Joshua T., Gomez, Timothy S., Gmyrek, Grzegorz B., Akilesh, Holly M., Dani, Adish, Billadeau, Daniel D., Swat, Wojciech
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041763/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041763/

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