Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms

Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms

A ‘lung cancer'-specific mutant EGFR interactome was generated by a global analysis of protein–protein interactions and phosphorylation. After functional screening, nine proteins were identified as essential for the viability of EGFR-mutant lung cancer cells.

Bibliographic Details
Main Authors: Li, Jiannong, Bennett, Keiryn, Stukalov, Alexey, Fang, Bin, Zhang, Guolin, Yoshida, Takeshi, Okamoto, Isamu, Kim, Jae-Young, Song, Lanxi, Bai, Yun, Qian, Xiaoning, Rawal, Bhupendra, Schell, Michael, Grebien, Florian, Winter, Georg, Rix, Uwe, Eschrich, Steven, Colinge, Jacques, Koomen, John, Superti-Furga, Giulio, Haura, Eric B
Format: Online
Language:English
Published: European Molecular Biology Organization 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039310/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039310/

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