Aberrant regulation of FBW7 in cancer
FBW7 (F-box and WD repeat domain-containing 7) or Fbxw7 is a tumor suppressor, which promotes the ubiquitination and subsequent degradation of numerous oncoproteins including Mcl-1, Cyclin E, Notch, c- Jun, and c-Myc. In turn, FBW7 is regulated by multiple upstream factors including p53, C/EBP-δ, EB...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Impact Journals LLC
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039140/ |