Ribosomal Protein Mutations Induce Autophagy through S6 Kinase Inhibition of the Insulin Pathway

Ribosomal Protein Mutations Induce Autophagy through S6 Kinase Inhibition of the Insulin Pathway

Mutations affecting the ribosome lead to several diseases known as ribosomopathies, with phenotypes that include growth defects, cytopenia, and bone marrow failure. Diamond-Blackfan anemia (DBA), for example, is a pure red cell aplasia linked to the mutation of ribosomal protein (RP) genes. Here we...

Full description

Bibliographic Details
Main Authors: Heijnen, Harry F., van Wijk, Richard, Pereboom, Tamara C., Goos, Yvonne J., Seinen, Cor W., van Oirschot, Brigitte A., van Dooren, Rowie, Gastou, Marc, Giles, Rachel H., van Solinge, Wouter, Kuijpers, Taco W., Gazda, Hanna T., Bierings, Marc B., Da Costa, Lydie, MacInnes, Alyson W.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038485/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038485/

Similar Items