Activating Transcription Factor 6 Is Necessary and Sufficient for Alcoholic Fatty Liver Disease in Zebrafish

Activating Transcription Factor 6 Is Necessary and Sufficient for Alcoholic Fatty Liver Disease in Zebrafish

Fatty liver disease (FLD) is characterized by lipid accumulation in hepatocytes and is accompanied by secretory pathway dysfunction, resulting in induction of the unfolded protein response (UPR). Activating transcription factor 6 (ATF6), one of three main UPR sensors, functions to both promote FLD d...

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Bibliographic Details
Main Authors: Howarth, Deanna L., Lindtner, Claudia, Vacaru, Ana M., Sachidanandam, Ravi, Tsedensodnom, Orkhontuya, Vasilkova, Taisa, Buettner, Christoph, Sadler, Kirsten C.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038464/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038464/

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