The Therapeutic Potential of Class I Selective Histone Deacetylase Inhibitors in Ovarian Cancer

Epithelial ovarian cancer remains the deadliest gynecologic malignancy. Despite advances in treatment, new approaches are needed. Histone deacetylases (HDACs) are a family of enzymes that regulate gene expression by removing acetyl groups from lysine residues on histones and non-histone proteins. In...

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Bibliographic Details
Main Author: Khabele, Dineo
Format: Online
Language:English
Published: Frontiers Media S.A. 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033132/