Panning for Long Noncoding RNAs

Panning for Long Noncoding RNAs

The recent advent of high-throughput approaches has revealed widespread transcription of the human genome, leading to a new appreciation of transcription regulation, especially from noncoding regions. Distinct from most coding and small noncoding RNAs, long noncoding RNAs (lncRNAs) are generally exp...

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Main Authors: Zhu, Shanshan, Zhang, Xiao-Ou, Yang, Li
Format: Online
Language:English
Published: MDPI 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030883/
id pubmed-4030883
recordtype oai_dc
spelling pubmed-40308832014-06-24 Panning for Long Noncoding RNAs Zhu, Shanshan Zhang, Xiao-Ou Yang, Li Review The recent advent of high-throughput approaches has revealed widespread transcription of the human genome, leading to a new appreciation of transcription regulation, especially from noncoding regions. Distinct from most coding and small noncoding RNAs, long noncoding RNAs (lncRNAs) are generally expressed at low levels, are less conserved and lack protein-coding capacity. These intrinsic features of lncRNAs have not only hampered their full annotation in the past several years, but have also generated controversy concerning whether many or most of these lncRNAs are simply the result of transcriptional noise. Here, we assess these intrinsic features that have challenged lncRNA discovery and further summarize recent progress in lncRNA discovery with integrated methodologies, from which new lessons and insights can be derived to achieve better characterization of lncRNA expression regulation. Full annotation of lncRNA repertoires and the implications of such annotation will provide a fundamental basis for comprehensive understanding of pervasive functions of lncRNAs in biological regulation. MDPI 2013-02-28 /pmc/articles/PMC4030883/ /pubmed/24970166 http://dx.doi.org/10.3390/biom3010226 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Zhu, Shanshan
Zhang, Xiao-Ou
Yang, Li
spellingShingle Zhu, Shanshan
Zhang, Xiao-Ou
Yang, Li
Panning for Long Noncoding RNAs
author_facet Zhu, Shanshan
Zhang, Xiao-Ou
Yang, Li
author_sort Zhu, Shanshan
title Panning for Long Noncoding RNAs
title_short Panning for Long Noncoding RNAs
title_full Panning for Long Noncoding RNAs
title_fullStr Panning for Long Noncoding RNAs
title_full_unstemmed Panning for Long Noncoding RNAs
title_sort panning for long noncoding rnas
description The recent advent of high-throughput approaches has revealed widespread transcription of the human genome, leading to a new appreciation of transcription regulation, especially from noncoding regions. Distinct from most coding and small noncoding RNAs, long noncoding RNAs (lncRNAs) are generally expressed at low levels, are less conserved and lack protein-coding capacity. These intrinsic features of lncRNAs have not only hampered their full annotation in the past several years, but have also generated controversy concerning whether many or most of these lncRNAs are simply the result of transcriptional noise. Here, we assess these intrinsic features that have challenged lncRNA discovery and further summarize recent progress in lncRNA discovery with integrated methodologies, from which new lessons and insights can be derived to achieve better characterization of lncRNA expression regulation. Full annotation of lncRNA repertoires and the implications of such annotation will provide a fundamental basis for comprehensive understanding of pervasive functions of lncRNAs in biological regulation.
publisher MDPI
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030883/
_version_ 1612092247165108224

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