Estimating telomere length from whole genome sequence data

Estimating telomere length from whole genome sequence data

Telomeres play a key role in replicative ageing and undergo age-dependent attrition in vivo. Here, we report a novel method, TelSeq, to measure average telomere length from whole genome or exome shotgun sequence data. In 260 leukocyte samples, we show that TelSeq results correlate with Southern blot...

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Main Authors: Ding, Zhihao, Mangino, Massimo, Aviv, Abraham, Spector, Tim, Durbin, Richard
Format: Online
Language:English
Published: Oxford University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027178/
id pubmed-4027178
recordtype oai_dc
spelling pubmed-40271782014-05-28 Estimating telomere length from whole genome sequence data Ding, Zhihao Mangino, Massimo Aviv, Abraham Spector, Tim Durbin, Richard Methods Online Telomeres play a key role in replicative ageing and undergo age-dependent attrition in vivo. Here, we report a novel method, TelSeq, to measure average telomere length from whole genome or exome shotgun sequence data. In 260 leukocyte samples, we show that TelSeq results correlate with Southern blot measurements of the mean length of terminal restriction fragments (mTRFs) and display age-dependent attrition comparably well as mTRFs. Oxford University Press 2014-05-01 2014-03-07 /pmc/articles/PMC4027178/ /pubmed/24609383 http://dx.doi.org/10.1093/nar/gku181 Text en © The Author(s) 2014. Published by Oxford University Press [on behalf of insert name of society]. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Ding, Zhihao
Mangino, Massimo
Aviv, Abraham
Spector, Tim
Durbin, Richard
spellingShingle Ding, Zhihao
Mangino, Massimo
Aviv, Abraham
Spector, Tim
Durbin, Richard
Estimating telomere length from whole genome sequence data
author_facet Ding, Zhihao
Mangino, Massimo
Aviv, Abraham
Spector, Tim
Durbin, Richard
author_sort Ding, Zhihao
title Estimating telomere length from whole genome sequence data
title_short Estimating telomere length from whole genome sequence data
title_full Estimating telomere length from whole genome sequence data
title_fullStr Estimating telomere length from whole genome sequence data
title_full_unstemmed Estimating telomere length from whole genome sequence data
title_sort estimating telomere length from whole genome sequence data
description Telomeres play a key role in replicative ageing and undergo age-dependent attrition in vivo. Here, we report a novel method, TelSeq, to measure average telomere length from whole genome or exome shotgun sequence data. In 260 leukocyte samples, we show that TelSeq results correlate with Southern blot measurements of the mean length of terminal restriction fragments (mTRFs) and display age-dependent attrition comparably well as mTRFs.
publisher Oxford University Press
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027178/
_version_ 1612091039612403712

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