Hearing in action; auditory properties of neurons in the red nucleus of alert primates

The response of neurons in the Red Nucleus pars magnocellularis (RNm) to both tone bursts and electrical stimulation were observed in three cynomolgus monkeys (Macaca fascicularis), in a series of studies primarily designed to characterize the influence of the dopaminergic ventral midbrain on audito...

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Main Authors:	Lovell, Jonathan M., Mylius, Judith, Scheich, Henning, Brosch, Michael
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026743/

id	pubmed-4026743
recordtype	oai_dc
spelling	pubmed-40267432014-05-23 Hearing in action; auditory properties of neurons in the red nucleus of alert primates Lovell, Jonathan M. Mylius, Judith Scheich, Henning Brosch, Michael Psychology The response of neurons in the Red Nucleus pars magnocellularis (RNm) to both tone bursts and electrical stimulation were observed in three cynomolgus monkeys (Macaca fascicularis), in a series of studies primarily designed to characterize the influence of the dopaminergic ventral midbrain on auditory processing. Compared to its role in motor behavior, little is known about the sensory response properties of neurons in the red nucleus (RN); particularly those concerning the auditory modality. Sites in the RN were recognized by observing electrically evoked body movements characteristic for this deep brain structure. In this study we applied brief monopolar electrical stimulation to 118 deep brain sites at a maximum intensity of 200 μA, thus evoking minimal body movements. Auditory sensitivity of RN neurons was analyzed more thoroughly at 15 sites, with the majority exhibiting broad tuning curves and phase locking up to 1.03 kHz. Since the RN appears to receive inputs from a very early stage of the ascending auditory system, our results suggest that sounds can modify the motor control exerted by this brain nucleus. At selected locations, we also tested for the presence of functional connections between the RN and the auditory cortex by inserting additional microelectrodes into the auditory cortex and investigating how action potentials and local field potentials (LFPs) were affected by electrical stimulation of the RN. Frontiers Media S.A. 2014-05-13 /pmc/articles/PMC4026743/ /pubmed/24860417 http://dx.doi.org/10.3389/fnins.2014.00105 Text en Copyright © 2014 Lovell, Mylius, Scheich and Brosch. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Lovell, Jonathan M. Mylius, Judith Scheich, Henning Brosch, Michael
spellingShingle	Lovell, Jonathan M. Mylius, Judith Scheich, Henning Brosch, Michael Hearing in action; auditory properties of neurons in the red nucleus of alert primates
author_facet	Lovell, Jonathan M. Mylius, Judith Scheich, Henning Brosch, Michael
author_sort	Lovell, Jonathan M.
title	Hearing in action; auditory properties of neurons in the red nucleus of alert primates
title_short	Hearing in action; auditory properties of neurons in the red nucleus of alert primates
title_full	Hearing in action; auditory properties of neurons in the red nucleus of alert primates
title_fullStr	Hearing in action; auditory properties of neurons in the red nucleus of alert primates
title_full_unstemmed	Hearing in action; auditory properties of neurons in the red nucleus of alert primates
title_sort	hearing in action; auditory properties of neurons in the red nucleus of alert primates
description	The response of neurons in the Red Nucleus pars magnocellularis (RNm) to both tone bursts and electrical stimulation were observed in three cynomolgus monkeys (Macaca fascicularis), in a series of studies primarily designed to characterize the influence of the dopaminergic ventral midbrain on auditory processing. Compared to its role in motor behavior, little is known about the sensory response properties of neurons in the red nucleus (RN); particularly those concerning the auditory modality. Sites in the RN were recognized by observing electrically evoked body movements characteristic for this deep brain structure. In this study we applied brief monopolar electrical stimulation to 118 deep brain sites at a maximum intensity of 200 μA, thus evoking minimal body movements. Auditory sensitivity of RN neurons was analyzed more thoroughly at 15 sites, with the majority exhibiting broad tuning curves and phase locking up to 1.03 kHz. Since the RN appears to receive inputs from a very early stage of the ascending auditory system, our results suggest that sounds can modify the motor control exerted by this brain nucleus. At selected locations, we also tested for the presence of functional connections between the RN and the auditory cortex by inserting additional microelectrodes into the auditory cortex and investigating how action potentials and local field potentials (LFPs) were affected by electrical stimulation of the RN.
publisher	Frontiers Media S.A.
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026743/
_version_	1612090867213926400

Hearing in action; auditory properties of neurons in the red nucleus of alert primates

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