Adiponectin Ameliorates Experimental Periodontitis in Diet-Induced Obesity Mice

Adiponectin is an adipokine that sensitizes the body to insulin. Low levels of adiponectin have been reported in obesity, diabetes and periodontitis. In this study we established experimental periodontitis in male adiponectin knockout and diet-induced obesity mice, a model of obesity and type 2 diab...

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Main Authors:	Zhang, Lan, Meng, Shu, Tu, Qisheng, Yu, Liming, Tang, Yin, Dard, Michel M., Kim, Sung-Hoon, Valverde, Paloma, Zhou, Xuedong, Chen, Jake
Format:	Online
Language:	English
Published:	Public Library of Science 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023953/

id	pubmed-4023953
recordtype	oai_dc
spelling	pubmed-40239532014-05-21 Adiponectin Ameliorates Experimental Periodontitis in Diet-Induced Obesity Mice Zhang, Lan Meng, Shu Tu, Qisheng Yu, Liming Tang, Yin Dard, Michel M. Kim, Sung-Hoon Valverde, Paloma Zhou, Xuedong Chen, Jake Research Article Adiponectin is an adipokine that sensitizes the body to insulin. Low levels of adiponectin have been reported in obesity, diabetes and periodontitis. In this study we established experimental periodontitis in male adiponectin knockout and diet-induced obesity mice, a model of obesity and type 2 diabetes, and aimed at evaluating the therapeutic potential of adiponectin. We found that systemic adiponectin infusion reduced alveolar bone loss, osteoclast activity and infiltration of inflammatory cells in both periodontitis mouse models. Furthermore, adiponectin treatment decreased the levels of pro-inflammatory cytokines in white adipose tissue of diet-induced obesity mice with experimental periodontitis. Our in vitro studies also revealed that forkhead box O1, a key transcriptional regulator of energy metabolism, played an important role in the direct signaling of adiponectin in osteoclasts. Thus, adiponectin increased forkhead box O1 mRNA expression and its nuclear protein level in osteoclast-precursor cells undergoing differentiation. Inhibition of c-Jun N-terminal kinase signaling decreased nuclear protein levels of forkhead box O1. Furthermore, over-expression of forkhead box O1 inhibited osteoclastogenesis and led to decreased nuclear levels of nuclear factor of activated T cells c1. Taken together, this study suggests that systemic adiponectin application may constitute a potential intervention therapy to ameliorate type 2 diabetes-associated periodontitis. It also proposes that adiponectin inhibition of osteoclastogenesis involves forkhead box O1. Public Library of Science 2014-05-16 /pmc/articles/PMC4023953/ /pubmed/24836538 http://dx.doi.org/10.1371/journal.pone.0097824 Text en © 2014 Zhang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Zhang, Lan Meng, Shu Tu, Qisheng Yu, Liming Tang, Yin Dard, Michel M. Kim, Sung-Hoon Valverde, Paloma Zhou, Xuedong Chen, Jake
spellingShingle	Zhang, Lan Meng, Shu Tu, Qisheng Yu, Liming Tang, Yin Dard, Michel M. Kim, Sung-Hoon Valverde, Paloma Zhou, Xuedong Chen, Jake Adiponectin Ameliorates Experimental Periodontitis in Diet-Induced Obesity Mice
author_facet	Zhang, Lan Meng, Shu Tu, Qisheng Yu, Liming Tang, Yin Dard, Michel M. Kim, Sung-Hoon Valverde, Paloma Zhou, Xuedong Chen, Jake
author_sort	Zhang, Lan
title	Adiponectin Ameliorates Experimental Periodontitis in Diet-Induced Obesity Mice
title_short	Adiponectin Ameliorates Experimental Periodontitis in Diet-Induced Obesity Mice
title_full	Adiponectin Ameliorates Experimental Periodontitis in Diet-Induced Obesity Mice
title_fullStr	Adiponectin Ameliorates Experimental Periodontitis in Diet-Induced Obesity Mice
title_full_unstemmed	Adiponectin Ameliorates Experimental Periodontitis in Diet-Induced Obesity Mice
title_sort	adiponectin ameliorates experimental periodontitis in diet-induced obesity mice
description	Adiponectin is an adipokine that sensitizes the body to insulin. Low levels of adiponectin have been reported in obesity, diabetes and periodontitis. In this study we established experimental periodontitis in male adiponectin knockout and diet-induced obesity mice, a model of obesity and type 2 diabetes, and aimed at evaluating the therapeutic potential of adiponectin. We found that systemic adiponectin infusion reduced alveolar bone loss, osteoclast activity and infiltration of inflammatory cells in both periodontitis mouse models. Furthermore, adiponectin treatment decreased the levels of pro-inflammatory cytokines in white adipose tissue of diet-induced obesity mice with experimental periodontitis. Our in vitro studies also revealed that forkhead box O1, a key transcriptional regulator of energy metabolism, played an important role in the direct signaling of adiponectin in osteoclasts. Thus, adiponectin increased forkhead box O1 mRNA expression and its nuclear protein level in osteoclast-precursor cells undergoing differentiation. Inhibition of c-Jun N-terminal kinase signaling decreased nuclear protein levels of forkhead box O1. Furthermore, over-expression of forkhead box O1 inhibited osteoclastogenesis and led to decreased nuclear levels of nuclear factor of activated T cells c1. Taken together, this study suggests that systemic adiponectin application may constitute a potential intervention therapy to ameliorate type 2 diabetes-associated periodontitis. It also proposes that adiponectin inhibition of osteoclastogenesis involves forkhead box O1.
publisher	Public Library of Science
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023953/
_version_	1612090116677828608

Adiponectin Ameliorates Experimental Periodontitis in Diet-Induced Obesity Mice

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