ROBUST PHOTO-REGULATION OF GABAA RECEPTORS BY ALLOSTERIC MODULATION WITH A PROPOFOL ANALOG

ROBUST PHOTO-REGULATION OF GABAA RECEPTORS BY ALLOSTERIC MODULATION WITH A PROPOFOL ANALOG

Photochemical switches represent a powerful method for improving pharmacological therapies and controlling cellular physiology. Here we report the photo-regulation of GABAA receptors (GABAARs) by a derivative of propofol (2,6-diisopropylphenol), a GABAAR allosteric modulator, that we have modified t...

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Bibliographic Details
Main Authors: Yue, Lan, Pawlowski, Michal, Dellal, Shlomo S., Xie, An, Feng, Feng, Otis, Thomas S., Bruzik, Karol S., Qian, Haohua, Pepperberg, David R.
Format: Online
Language:English
Published: 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023869/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023869/

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