Intra-tumoral Metastatic Double Primary Carcinoma: Synchronous Metastatic Tumor in Lung from Breast and Thyroid Carcinoma

Cases of phenotypic heterogeneity of cells within tumors have recently been reported. Here, we report on a patient with characteristic intra-tumor double primary metastases in the lung. This patient was a 40-year-old Korean woman who had been diagnosed with breast cancer (T1N0M0, estrogen receptor/p...

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Main Authors:	Park, Lee Chun, Jeong, Ji Yun, Ji, Jun Ho, Park, Silvia, Ahn, Jin Seok, Im, Young-Hyuck, Park, Yeon Hee
Format:	Online
Language:	English
Published:	Korean Cancer Association 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022830/

id	pubmed-4022830
recordtype	oai_dc
spelling	pubmed-40228302014-05-21 Intra-tumoral Metastatic Double Primary Carcinoma: Synchronous Metastatic Tumor in Lung from Breast and Thyroid Carcinoma Park, Lee Chun Jeong, Ji Yun Ji, Jun Ho Park, Silvia Ahn, Jin Seok Im, Young-Hyuck Park, Yeon Hee Case Report Cases of phenotypic heterogeneity of cells within tumors have recently been reported. Here, we report on a patient with characteristic intra-tumor double primary metastases in the lung. This patient was a 40-year-old Korean woman who had been diagnosed with breast cancer (T1N0M0, estrogen receptor/progesterone receptor/HER2 +/+/+) and papillary thyroid cancer three years prior and underwent a complete surgical resection followed by appropriate adjuvant treatment with radiation, hormone, and radioactive iodine. She was recently admitted for newly developed pulmonary nodules. Metastasectomy through video-assisted thoracoscopic surgery revealed recurrent double primary cancer with two different components (metastatic ductal carcinomas from the breast and metastatic papillary carcinomas from the thyroid gland) in each pulmonary nodule in the right upper lobe and right middle lobe. To the best of our knowledge, this is the first report of simultaneous recurrent double metastasis in one organ from different primary origins. Korean Cancer Association 2014-04 2014-04-22 /pmc/articles/PMC4022830/ /pubmed/24851113 http://dx.doi.org/10.4143/crt.2014.46.2.200 Text en Copyright © 2014 by the Korean Cancer Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Park, Lee Chun Jeong, Ji Yun Ji, Jun Ho Park, Silvia Ahn, Jin Seok Im, Young-Hyuck Park, Yeon Hee
spellingShingle	Park, Lee Chun Jeong, Ji Yun Ji, Jun Ho Park, Silvia Ahn, Jin Seok Im, Young-Hyuck Park, Yeon Hee Intra-tumoral Metastatic Double Primary Carcinoma: Synchronous Metastatic Tumor in Lung from Breast and Thyroid Carcinoma
author_facet	Park, Lee Chun Jeong, Ji Yun Ji, Jun Ho Park, Silvia Ahn, Jin Seok Im, Young-Hyuck Park, Yeon Hee
author_sort	Park, Lee Chun
title	Intra-tumoral Metastatic Double Primary Carcinoma: Synchronous Metastatic Tumor in Lung from Breast and Thyroid Carcinoma
title_short	Intra-tumoral Metastatic Double Primary Carcinoma: Synchronous Metastatic Tumor in Lung from Breast and Thyroid Carcinoma
title_full	Intra-tumoral Metastatic Double Primary Carcinoma: Synchronous Metastatic Tumor in Lung from Breast and Thyroid Carcinoma
title_fullStr	Intra-tumoral Metastatic Double Primary Carcinoma: Synchronous Metastatic Tumor in Lung from Breast and Thyroid Carcinoma
title_full_unstemmed	Intra-tumoral Metastatic Double Primary Carcinoma: Synchronous Metastatic Tumor in Lung from Breast and Thyroid Carcinoma
title_sort	intra-tumoral metastatic double primary carcinoma: synchronous metastatic tumor in lung from breast and thyroid carcinoma
description	Cases of phenotypic heterogeneity of cells within tumors have recently been reported. Here, we report on a patient with characteristic intra-tumor double primary metastases in the lung. This patient was a 40-year-old Korean woman who had been diagnosed with breast cancer (T1N0M0, estrogen receptor/progesterone receptor/HER2 +/+/+) and papillary thyroid cancer three years prior and underwent a complete surgical resection followed by appropriate adjuvant treatment with radiation, hormone, and radioactive iodine. She was recently admitted for newly developed pulmonary nodules. Metastasectomy through video-assisted thoracoscopic surgery revealed recurrent double primary cancer with two different components (metastatic ductal carcinomas from the breast and metastatic papillary carcinomas from the thyroid gland) in each pulmonary nodule in the right upper lobe and right middle lobe. To the best of our knowledge, this is the first report of simultaneous recurrent double metastasis in one organ from different primary origins.
publisher	Korean Cancer Association
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022830/
_version_	1612089821648388096

Intra-tumoral Metastatic Double Primary Carcinoma: Synchronous Metastatic Tumor in Lung from Breast and Thyroid Carcinoma

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