Enhanced Adipogenicity of Bone Marrow Mesenchymal Stem Cells in Aplastic Anemia

Enhanced Adipogenicity of Bone Marrow Mesenchymal Stem Cells in Aplastic Anemia

Fatty bone marrow (BM) and defective hematopoiesis are a pathologic hallmark of aplastic anemia (AA). We have investigated adipogenic and osteogenic potential of BM mesenchymal stem cells (BM-MSC) in 10 AA patients (08 males and 02 females) with median age of 37 years (range: 06 to 79 years) and in...

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Main Authors: Tripathy, Naresh Kumar, Singh, Saurabh Pratap, Nityanand, Soniya
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021843/
id pubmed-4021843
recordtype oai_dc
spelling pubmed-40218432014-05-29 Enhanced Adipogenicity of Bone Marrow Mesenchymal Stem Cells in Aplastic Anemia Tripathy, Naresh Kumar Singh, Saurabh Pratap Nityanand, Soniya Research Article Fatty bone marrow (BM) and defective hematopoiesis are a pathologic hallmark of aplastic anemia (AA). We have investigated adipogenic and osteogenic potential of BM mesenchymal stem cells (BM-MSC) in 10 AA patients (08 males and 02 females) with median age of 37 years (range: 06 to 79 years) and in the same number of age and sex matched controls. It was observed that BM-MSC of AA patients had a morphology, phenotype, and osteogenic differentiation potential similar to control subjects but adipocytes differentiated from AA BM-MSC had a higher density and larger size of lipid droplets and they expressed significantly higher levels of adiponectin and FABP4 genes and proteins as compared to control BM-MSC (P < 0.01 for both). Thus our data shows that AA BM-MSC have enhanced adipogenicity, which may have an important implication in the pathogenesis of the disease. Hindawi Publishing Corporation 2014 2014-04-30 /pmc/articles/PMC4021843/ /pubmed/24876847 http://dx.doi.org/10.1155/2014/276862 Text en Copyright © 2014 Naresh Kumar Tripathy et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Tripathy, Naresh Kumar
Singh, Saurabh Pratap
Nityanand, Soniya
spellingShingle Tripathy, Naresh Kumar
Singh, Saurabh Pratap
Nityanand, Soniya
Enhanced Adipogenicity of Bone Marrow Mesenchymal Stem Cells in Aplastic Anemia
author_facet Tripathy, Naresh Kumar
Singh, Saurabh Pratap
Nityanand, Soniya
author_sort Tripathy, Naresh Kumar
title Enhanced Adipogenicity of Bone Marrow Mesenchymal Stem Cells in Aplastic Anemia
title_short Enhanced Adipogenicity of Bone Marrow Mesenchymal Stem Cells in Aplastic Anemia
title_full Enhanced Adipogenicity of Bone Marrow Mesenchymal Stem Cells in Aplastic Anemia
title_fullStr Enhanced Adipogenicity of Bone Marrow Mesenchymal Stem Cells in Aplastic Anemia
title_full_unstemmed Enhanced Adipogenicity of Bone Marrow Mesenchymal Stem Cells in Aplastic Anemia
title_sort enhanced adipogenicity of bone marrow mesenchymal stem cells in aplastic anemia
description Fatty bone marrow (BM) and defective hematopoiesis are a pathologic hallmark of aplastic anemia (AA). We have investigated adipogenic and osteogenic potential of BM mesenchymal stem cells (BM-MSC) in 10 AA patients (08 males and 02 females) with median age of 37 years (range: 06 to 79 years) and in the same number of age and sex matched controls. It was observed that BM-MSC of AA patients had a morphology, phenotype, and osteogenic differentiation potential similar to control subjects but adipocytes differentiated from AA BM-MSC had a higher density and larger size of lipid droplets and they expressed significantly higher levels of adiponectin and FABP4 genes and proteins as compared to control BM-MSC (P < 0.01 for both). Thus our data shows that AA BM-MSC have enhanced adipogenicity, which may have an important implication in the pathogenesis of the disease.
publisher Hindawi Publishing Corporation
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021843/
_version_ 1612089366064136192

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