Controlling the receptor for advanced glycation end‐products to conquer diabetic vascular complications

Diabetic vascular complications, such as cardiovascular disease, stroke and microangiopathy, lead to high rates of morbidity and mortality in patients with long‐term diabetes. Extensive intracellular and extracellular formation of advanced glycation end‐products (AGE) is considered a causative facto...

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Main Authors:	Yamamoto, Yasuhiko, Yamamoto, Hiroshi
Format:	Online
Language:	English
Published:	Blackwell Publishing Ltd 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020727/

id	pubmed-4020727
recordtype	oai_dc
spelling	pubmed-40207272014-05-19 Controlling the receptor for advanced glycation end‐products to conquer diabetic vascular complications Yamamoto, Yasuhiko Yamamoto, Hiroshi Review Articles Diabetic vascular complications, such as cardiovascular disease, stroke and microangiopathy, lead to high rates of morbidity and mortality in patients with long‐term diabetes. Extensive intracellular and extracellular formation of advanced glycation end‐products (AGE) is considered a causative factor in vascular injuries in diabetes. Receptor‐dependent mechanisms are involved in AGE‐induced cellular dysfunction and tissue damage. The receptor for AGE (RAGE), originally an AGE‐binding receptor, is now recognized as a member of pattern‐recognition receptors and a pro‐inflammatory molecular device that mediates danger signals to the body. Previous animal studies have shown RAGE dependent of diabetic vascular injuries. Prophylactic and therapeutic strategies focusing on RAGE and its ligand axis will be of great importance in conquering diabetic vascular complications. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.2011.00191.x, 2012) Blackwell Publishing Ltd 2012-01-27 2012-03-28 /pmc/articles/PMC4020727/ /pubmed/24843553 http://dx.doi.org/10.1111/j.2040-1124.2011.00191.x Text en © 2012 Asian Association for the Study of Diabetes and Blackwell Publishing Asia Pty Ltd
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Yamamoto, Yasuhiko Yamamoto, Hiroshi
spellingShingle	Yamamoto, Yasuhiko Yamamoto, Hiroshi Controlling the receptor for advanced glycation end‐products to conquer diabetic vascular complications
author_facet	Yamamoto, Yasuhiko Yamamoto, Hiroshi
author_sort	Yamamoto, Yasuhiko
title	Controlling the receptor for advanced glycation end‐products to conquer diabetic vascular complications
title_short	Controlling the receptor for advanced glycation end‐products to conquer diabetic vascular complications
title_full	Controlling the receptor for advanced glycation end‐products to conquer diabetic vascular complications
title_fullStr	Controlling the receptor for advanced glycation end‐products to conquer diabetic vascular complications
title_full_unstemmed	Controlling the receptor for advanced glycation end‐products to conquer diabetic vascular complications
title_sort	controlling the receptor for advanced glycation end‐products to conquer diabetic vascular complications
description	Diabetic vascular complications, such as cardiovascular disease, stroke and microangiopathy, lead to high rates of morbidity and mortality in patients with long‐term diabetes. Extensive intracellular and extracellular formation of advanced glycation end‐products (AGE) is considered a causative factor in vascular injuries in diabetes. Receptor‐dependent mechanisms are involved in AGE‐induced cellular dysfunction and tissue damage. The receptor for AGE (RAGE), originally an AGE‐binding receptor, is now recognized as a member of pattern‐recognition receptors and a pro‐inflammatory molecular device that mediates danger signals to the body. Previous animal studies have shown RAGE dependent of diabetic vascular injuries. Prophylactic and therapeutic strategies focusing on RAGE and its ligand axis will be of great importance in conquering diabetic vascular complications. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.2011.00191.x, 2012)
publisher	Blackwell Publishing Ltd
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020727/
_version_	1612088874889117696

Controlling the receptor for advanced glycation end‐products to conquer diabetic vascular complications

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