Functional Production of a Soluble and Secreted Single-Chain Antibody by a Bacterial Secretion System

Functional Production of a Soluble and Secreted Single-Chain Antibody by a Bacterial Secretion System

Single-chain variable fragments (scFvs) serve as an alternative to full-length monoclonal antibodies used in research and therapeutic and diagnostic applications. However, when recombinant scFvs are overexpressed in bacteria, they often form inclusion bodies and exhibit loss of function. To overcome...

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Bibliographic Details
Main Authors: Cheng, Chiu-Min, Tzou, Shey-Cherng, Zhuang, Ya-Han, Huang, Chien-Chiao, Kao, Chien-Han, Liao, Kuang-Wen, Cheng, Ta-Chun, Chuang, Chih-Hung, Hsieh, Yuan-Chin, Tai, Ming-Hong, Cheng, Tian-Lu
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019604/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019604/

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