Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

Recent epidemiological and laboratory-based studies suggest that the anti-diabetic drug metformin prevents cancer progression. How metformin diminishes tumor growth is not fully understood. In this study, we report that in human cancer cells, metformin inhibits mitochondrial complex I (NADH dehydrog...

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Bibliographic Details
Main Authors: Wheaton, William W, Weinberg, Samuel E, Hamanaka, Robert B, Soberanes, Saul, Sullivan, Lucas B, Anso, Elena, Glasauer, Andrea, Dufour, Eric, Mutlu, Gokhan M, Budigner, GR Scott, Chandel, Navdeep S
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017650/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017650/

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