Gastric cardia adenocarcinoma pathway analysis

Gastric cardia adenocarcinoma pathway analysis

Gastric cardia adenocarcinoma (GCA)is one of the few malignancies with unexplained reasons that have increased sharply in developed countries. The purpose of this review was to determine the pathways in GCA to identify new biomarker. So by comparing gene expression in GCA group with normal control i...

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Main Authors: Zali, Hakimeh, Rezaei-Tavirani, Mostafa, Vafaee, Reza, Rezaei-Tavirani, Majid
Format: Online
Language:English
Published: Research Institute for Gastroenterology and Liver Diseases 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017529/
id pubmed-4017529
recordtype oai_dc
spelling pubmed-40175292014-05-15 Gastric cardia adenocarcinoma pathway analysis Zali, Hakimeh Rezaei-Tavirani, Mostafa Vafaee, Reza Rezaei-Tavirani, Majid Original Article Gastric cardia adenocarcinoma (GCA)is one of the few malignancies with unexplained reasons that have increased sharply in developed countries. The purpose of this review was to determine the pathways in GCA to identify new biomarker. So by comparing gene expression in GCA group with normal control identified important pathways. Gene expression data were extracted from the beforehand investigations then differentially expressed genes utilized in DAVID program to explorer and find related pathways. Our findings contain 367 gene names. Out of these 367 proteins, 199 were found to be exclusively expressed in GCA; whereas 168 proteins were detected down-regulated or silenced. The GCA associated diseases based on the differently expressed genes made up of diseases pathway related colorectal cancer, small cell lung cancer, breast cancer and H. pylori infection stomach cancer. KEGG pathways related to GCA contained cell cycle, p53 signaling pathway, DNA replication, toll-like receptor signaling pathway and some other diseases. The GO-discovered categories also demonstrated most biological process and molecular function related to cancer. Up until now, there is no report to introduce influential biomarkers in GCA so, the deregulated genes identified in GCA patterns might be helpful for diagnosis, prognosis and therapies for gastric cancer but validation of these biomarkers is necessary. Research Institute for Gastroenterology and Liver Diseases 2013 /pmc/articles/PMC4017529/ /pubmed/24834279 Text en Copyright © 2013 Research Institute for Gastroenterology and Liver Diseases http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Zali, Hakimeh
Rezaei-Tavirani, Mostafa
Vafaee, Reza
Rezaei-Tavirani, Majid
spellingShingle Zali, Hakimeh
Rezaei-Tavirani, Mostafa
Vafaee, Reza
Rezaei-Tavirani, Majid
Gastric cardia adenocarcinoma pathway analysis
author_facet Zali, Hakimeh
Rezaei-Tavirani, Mostafa
Vafaee, Reza
Rezaei-Tavirani, Majid
author_sort Zali, Hakimeh
title Gastric cardia adenocarcinoma pathway analysis
title_short Gastric cardia adenocarcinoma pathway analysis
title_full Gastric cardia adenocarcinoma pathway analysis
title_fullStr Gastric cardia adenocarcinoma pathway analysis
title_full_unstemmed Gastric cardia adenocarcinoma pathway analysis
title_sort gastric cardia adenocarcinoma pathway analysis
description Gastric cardia adenocarcinoma (GCA)is one of the few malignancies with unexplained reasons that have increased sharply in developed countries. The purpose of this review was to determine the pathways in GCA to identify new biomarker. So by comparing gene expression in GCA group with normal control identified important pathways. Gene expression data were extracted from the beforehand investigations then differentially expressed genes utilized in DAVID program to explorer and find related pathways. Our findings contain 367 gene names. Out of these 367 proteins, 199 were found to be exclusively expressed in GCA; whereas 168 proteins were detected down-regulated or silenced. The GCA associated diseases based on the differently expressed genes made up of diseases pathway related colorectal cancer, small cell lung cancer, breast cancer and H. pylori infection stomach cancer. KEGG pathways related to GCA contained cell cycle, p53 signaling pathway, DNA replication, toll-like receptor signaling pathway and some other diseases. The GO-discovered categories also demonstrated most biological process and molecular function related to cancer. Up until now, there is no report to introduce influential biomarkers in GCA so, the deregulated genes identified in GCA patterns might be helpful for diagnosis, prognosis and therapies for gastric cancer but validation of these biomarkers is necessary.
publisher Research Institute for Gastroenterology and Liver Diseases
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017529/
_version_ 1612087925923643392

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