Initiation of Translation by Cricket Paralysis Virus IRES Requires Its Translocation in the Ribosome

The cricket paralysis virus internal ribosome entry site (CrPV-IRES) is a folded structure in a viral mRNA that allows initiation of translation in the absence of any host initiation factors. By using recent advances in single-particle electron cryomicroscopy, we have solved the structure of CrPV-IR...

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Bibliographic Details
Main Authors: Fernández, Israel S., Bai, Xiao-Chen, Murshudov, Garib, Scheres, Sjors H.W., Ramakrishnan, V.
Format: Online
Language:English
Published: Cell Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017093/