Latest insights into the risk of cancer in diabetes
A growing body of evidence from observational studies and meta‐analyses of the data suggest that diabetes mellitus is associated with an increased risk of cancer. Meta‐analyses have shown that diabetes increases the risks of total cancer, and of site‐specific cancers of the breast, endometrium, blad...
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| Format: | Online |
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Wiley-Blackwell
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015656/ |
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pubmed-40156562014-05-19 Latest insights into the risk of cancer in diabetes Noto, Hiroshi Goto, Atsushi Tsujimoto, Tetsuro Osame, Keiichiro Noda, Mitsuhiko Review Articles A growing body of evidence from observational studies and meta‐analyses of the data suggest that diabetes mellitus is associated with an increased risk of cancer. Meta‐analyses have shown that diabetes increases the risks of total cancer, and of site‐specific cancers of the breast, endometrium, bladder, liver, colorectum and pancreas, and that it decreases the risk of prostate cancer. Insulin resistance and secondary hyperinsulinemia is the most frequently proposed hypothesis, and hyperglycemia itself might promote carcinogenesis. In addition to several facets of lifestyle including obesity, smoking and lack of exercise, treatment for diabetes might affect the risk of cancer. For instance, metformin, an insulin sensitizer, reportedly has a potential anticancer effect. In light of the exploding global epidemic of diabetes, even a modest increase in the cancer risk will translate into a substantial socioeconomic burden. The current insights underscore the need for clinical attention and better‐designed studies of the complex interactions between diabetes and cancer. Wiley-Blackwell 2013-05-06 2013-05-06 /pmc/articles/PMC4015656/ /pubmed/24843658 http://dx.doi.org/10.1111/jdi.12068 Text en © 2013 Asian Association for the Study of Diabetes and Wiley Publishing Asia Pty Ltd |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Noto, Hiroshi Goto, Atsushi Tsujimoto, Tetsuro Osame, Keiichiro Noda, Mitsuhiko |
| spellingShingle |
Noto, Hiroshi Goto, Atsushi Tsujimoto, Tetsuro Osame, Keiichiro Noda, Mitsuhiko Latest insights into the risk of cancer in diabetes |
| author_facet |
Noto, Hiroshi Goto, Atsushi Tsujimoto, Tetsuro Osame, Keiichiro Noda, Mitsuhiko |
| author_sort |
Noto, Hiroshi |
| title |
Latest insights into the risk of cancer in diabetes |
| title_short |
Latest insights into the risk of cancer in diabetes |
| title_full |
Latest insights into the risk of cancer in diabetes |
| title_fullStr |
Latest insights into the risk of cancer in diabetes |
| title_full_unstemmed |
Latest insights into the risk of cancer in diabetes |
| title_sort |
latest insights into the risk of cancer in diabetes |
| description |
A growing body of evidence from observational studies and meta‐analyses of the data suggest that diabetes mellitus is associated with an increased risk of cancer. Meta‐analyses have shown that diabetes increases the risks of total cancer, and of site‐specific cancers of the breast, endometrium, bladder, liver, colorectum and pancreas, and that it decreases the risk of prostate cancer. Insulin resistance and secondary hyperinsulinemia is the most frequently proposed hypothesis, and hyperglycemia itself might promote carcinogenesis. In addition to several facets of lifestyle including obesity, smoking and lack of exercise, treatment for diabetes might affect the risk of cancer. For instance, metformin, an insulin sensitizer, reportedly has a potential anticancer effect. In light of the exploding global epidemic of diabetes, even a modest increase in the cancer risk will translate into a substantial socioeconomic burden. The current insights underscore the need for clinical attention and better‐designed studies of the complex interactions between diabetes and cancer. |
| publisher |
Wiley-Blackwell |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015656/ |
| _version_ |
1612087219905888256 |