An Unbiased Proteomic Screen Reveals Caspase Cleavage Is Positively and Negatively Regulated by Substrate Phosphorylation*

An Unbiased Proteomic Screen Reveals Caspase Cleavage Is Positively and Negatively Regulated by Substrate Phosphorylation*

Post-translational modifications of proteins regulate diverse cellular functions, with mounting evidence suggesting that hierarchical cross-talk between distinct modifications may fine-tune cellular responses. For example, in apoptosis, caspases promote cell death via cleavage of key structural and...

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Bibliographic Details
Main Authors: Turowec, Jacob P., Zukowski, Stephanie A., Knight, James D. R., Smalley, David M., Graves, Lee M., Johnson, Gary L., Li, Shawn S. C., Lajoie, Gilles A., Litchfield, David W.
Format: Online
Language:English
Published: The American Society for Biochemistry and Molecular Biology 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014278/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014278/

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