Inhibition of the JAK2/STAT3 Pathway Reduces Gastric Cancer Growth In Vitro and In Vivo

Inhibition of the JAK2/STAT3 Pathway Reduces Gastric Cancer Growth In Vitro and In Vivo

Signal Transducer and Activator of Transcription-3 (STAT3) is constitutively activated in many cancers where it promotes growth, inflammation, angiogenesis and inhibits apoptosis. We have shown that STAT3 is constitutively activated in human gastric cancer, and that chronic IL-11-driven STAT3 transc...

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Bibliographic Details
Main Authors: Judd, Louise M., Menheniott, Treve R., Ling, Hui, Jackson, Cameron B., Howlett, Meegan, Kalantzis, Anastasia, Priebe, Waldemar, Giraud, Andrew S.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013079/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013079/

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