Action of Clathrodin and Analogues on Voltage-Gated Sodium Channels

Clathrodin is a marine alkaloid and believed to be a modulator of voltage-gated sodium (NaV ) channels. Since there is an urgent need for small molecule NaV channel ligands as novel therapeutics, clathrodin could represent an interesting lead compound. Therefore, clathrodin was reinvestigated for it...

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Bibliographic Details
Main Authors: Peigneur, Steve, Žula, Aleš, Zidar, Nace, Chan-Porter, Fiona, Kirby, Robert, Madge, David, Ilaš, Janez, Kikelj, Danijel, Tytgat, Jan
Format: Online
Language:English
Published: MDPI 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012458/