Serum Fibroblast Growth Factor 21 Levels Are Correlated with the Severity of Diabetic Retinopathy

The aim of the study was to assess serum fibroblast growth factor 21 (FGF21) concentrations in Chinese type 2 diabetic patients with and without retinopathy and to assess the association between FGF21 and the severity of retinopathy. 117 diabetic patients were compared with 68 healthy controls. Fast...

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Main Authors:	Lin, Yuan, Xiao, Ye-cheng, Zhu, Hong, Xu, Qing-yan, Qi, Lei, Wang, Yu-bin, Li, Xiu-juan, Zheng, Ma-li, Zhong, Rui-sheng, Zhang, Yi, Xu, Xiang-dong, Wu, Bo-le, Xu, Zhu-mei, Lu, Xiang-hong
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009259/

id	pubmed-4009259
recordtype	oai_dc
spelling	pubmed-40092592014-06-03 Serum Fibroblast Growth Factor 21 Levels Are Correlated with the Severity of Diabetic Retinopathy Lin, Yuan Xiao, Ye-cheng Zhu, Hong Xu, Qing-yan Qi, Lei Wang, Yu-bin Li, Xiu-juan Zheng, Ma-li Zhong, Rui-sheng Zhang, Yi Xu, Xiang-dong Wu, Bo-le Xu, Zhu-mei Lu, Xiang-hong Research Article The aim of the study was to assess serum fibroblast growth factor 21 (FGF21) concentrations in Chinese type 2 diabetic patients with and without retinopathy and to assess the association between FGF21 and the severity of retinopathy. 117 diabetic patients were compared with 68 healthy controls. Fasting blood glucose, serum total cholesterol, serum triglycerides, serum insulin, and serum FGF21 levels were estimated. FGF21 concentrations in the patients were significantly higher than those in control. In the patient group there was a significant positive correlation between FGF21, insulin level, and homeostasis model assessment index. Serum FGF21 concentrations in patients with proliferative diabetic retinopathy or nonproliferative diabetic retinopathy were significantly higher than those in patients without diabetic retinopathy. When the presence of diabetes was defined as the final variable in the conditional logistic regression model with the FGF21 concentration as the continuous variable, FGF21 was significantly involved in the model. This study shows that the increase in serum concentration of FGF21 was associated with the severity of diabetic retinopathy and suggests that FGF21 may play a role in the pathogenesis of diabetic retinopathy and its degree. Hindawi Publishing Corporation 2014 2014-04-15 /pmc/articles/PMC4009259/ /pubmed/24895642 http://dx.doi.org/10.1155/2014/929756 Text en Copyright © 2014 Yuan Lin et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Lin, Yuan Xiao, Ye-cheng Zhu, Hong Xu, Qing-yan Qi, Lei Wang, Yu-bin Li, Xiu-juan Zheng, Ma-li Zhong, Rui-sheng Zhang, Yi Xu, Xiang-dong Wu, Bo-le Xu, Zhu-mei Lu, Xiang-hong
spellingShingle	Lin, Yuan Xiao, Ye-cheng Zhu, Hong Xu, Qing-yan Qi, Lei Wang, Yu-bin Li, Xiu-juan Zheng, Ma-li Zhong, Rui-sheng Zhang, Yi Xu, Xiang-dong Wu, Bo-le Xu, Zhu-mei Lu, Xiang-hong Serum Fibroblast Growth Factor 21 Levels Are Correlated with the Severity of Diabetic Retinopathy
author_facet	Lin, Yuan Xiao, Ye-cheng Zhu, Hong Xu, Qing-yan Qi, Lei Wang, Yu-bin Li, Xiu-juan Zheng, Ma-li Zhong, Rui-sheng Zhang, Yi Xu, Xiang-dong Wu, Bo-le Xu, Zhu-mei Lu, Xiang-hong
author_sort	Lin, Yuan
title	Serum Fibroblast Growth Factor 21 Levels Are Correlated with the Severity of Diabetic Retinopathy
title_short	Serum Fibroblast Growth Factor 21 Levels Are Correlated with the Severity of Diabetic Retinopathy
title_full	Serum Fibroblast Growth Factor 21 Levels Are Correlated with the Severity of Diabetic Retinopathy
title_fullStr	Serum Fibroblast Growth Factor 21 Levels Are Correlated with the Severity of Diabetic Retinopathy
title_full_unstemmed	Serum Fibroblast Growth Factor 21 Levels Are Correlated with the Severity of Diabetic Retinopathy
title_sort	serum fibroblast growth factor 21 levels are correlated with the severity of diabetic retinopathy
description	The aim of the study was to assess serum fibroblast growth factor 21 (FGF21) concentrations in Chinese type 2 diabetic patients with and without retinopathy and to assess the association between FGF21 and the severity of retinopathy. 117 diabetic patients were compared with 68 healthy controls. Fasting blood glucose, serum total cholesterol, serum triglycerides, serum insulin, and serum FGF21 levels were estimated. FGF21 concentrations in the patients were significantly higher than those in control. In the patient group there was a significant positive correlation between FGF21, insulin level, and homeostasis model assessment index. Serum FGF21 concentrations in patients with proliferative diabetic retinopathy or nonproliferative diabetic retinopathy were significantly higher than those in patients without diabetic retinopathy. When the presence of diabetes was defined as the final variable in the conditional logistic regression model with the FGF21 concentration as the continuous variable, FGF21 was significantly involved in the model. This study shows that the increase in serum concentration of FGF21 was associated with the severity of diabetic retinopathy and suggests that FGF21 may play a role in the pathogenesis of diabetic retinopathy and its degree.
publisher	Hindawi Publishing Corporation
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009259/
_version_	1612085120246743040

Serum Fibroblast Growth Factor 21 Levels Are Correlated with the Severity of Diabetic Retinopathy

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