Cancer Stem Cell Marker Musashi-1 rs2522137 Genotype Is Associated with an Increased Risk of Lung Cancer

Gene single nucleotide polymorphisms (SNPs) have been extensively studied in association with development and prognosis of various malignancies. However, the potential role of genetic polymorphisms of cancer stem cell (CSC) marker genes with respect to cancer risk has not been examined. We conducted...

Full description

Bibliographic Details
Main Authors:	Wang, Xu, Hu, Ji-Fan, Tan, Yehui, Cui, Jiuwei, Wang, Guanjun, Mrsny, Randall J., Li, Wei
Format:	Online
Language:	English
Published:	Public Library of Science 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008537/

id	pubmed-4008537
recordtype	oai_dc
spelling	pubmed-40085372014-05-09 Cancer Stem Cell Marker Musashi-1 rs2522137 Genotype Is Associated with an Increased Risk of Lung Cancer Wang, Xu Hu, Ji-Fan Tan, Yehui Cui, Jiuwei Wang, Guanjun Mrsny, Randall J. Li, Wei Research Article Gene single nucleotide polymorphisms (SNPs) have been extensively studied in association with development and prognosis of various malignancies. However, the potential role of genetic polymorphisms of cancer stem cell (CSC) marker genes with respect to cancer risk has not been examined. We conducted a case-control study involving a total of 1000 subjects (500 lung cancer patients and 500 age-matched cancer-free controls) from northeastern China. Lung cancer risk was analyzed in a logistic regression model in association with genotypes of four lung CSC marker genes (CD133, ALDH1, Musashi-1, and EpCAM). Using univariate analysis, the Musashi-1 rs2522137 GG genotype was found to be associated with a higher incidence of lung cancer compared with the TT genotype. No significant associations were observed for gene variants of CD133, ALDH1, or EpCAM. In multivariate analysis, Musashi-1 rs2522137 was still significantly associated with lung cancer when environmental and lifestyle factors were incorporated in the model, including lower BMI; family history of cancer; prior diagnosis of chronic obstructive pulmonary disease, pneumonia, or pulmonary tuberculosis; occupational exposure to pesticide; occupational exposure to gasoline or diesel fuel; heavier smoking; and exposure to heavy cooking emissions. The value of the area under the receiver-operating characteristic (ROC) curve (AUC) was 0.7686. To our knowledge, this is the first report to show an association between a Musashi-1 genotype and lung cancer risk. Further, the prediction model in this study may be useful in determining individuals with high risk of lung cancer. Public Library of Science 2014-05-02 /pmc/articles/PMC4008537/ /pubmed/24787949 http://dx.doi.org/10.1371/journal.pone.0095915 Text en © 2014 Wang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Wang, Xu Hu, Ji-Fan Tan, Yehui Cui, Jiuwei Wang, Guanjun Mrsny, Randall J. Li, Wei
spellingShingle	Wang, Xu Hu, Ji-Fan Tan, Yehui Cui, Jiuwei Wang, Guanjun Mrsny, Randall J. Li, Wei Cancer Stem Cell Marker Musashi-1 rs2522137 Genotype Is Associated with an Increased Risk of Lung Cancer
author_facet	Wang, Xu Hu, Ji-Fan Tan, Yehui Cui, Jiuwei Wang, Guanjun Mrsny, Randall J. Li, Wei
author_sort	Wang, Xu
title	Cancer Stem Cell Marker Musashi-1 rs2522137 Genotype Is Associated with an Increased Risk of Lung Cancer
title_short	Cancer Stem Cell Marker Musashi-1 rs2522137 Genotype Is Associated with an Increased Risk of Lung Cancer
title_full	Cancer Stem Cell Marker Musashi-1 rs2522137 Genotype Is Associated with an Increased Risk of Lung Cancer
title_fullStr	Cancer Stem Cell Marker Musashi-1 rs2522137 Genotype Is Associated with an Increased Risk of Lung Cancer
title_full_unstemmed	Cancer Stem Cell Marker Musashi-1 rs2522137 Genotype Is Associated with an Increased Risk of Lung Cancer
title_sort	cancer stem cell marker musashi-1 rs2522137 genotype is associated with an increased risk of lung cancer
description	Gene single nucleotide polymorphisms (SNPs) have been extensively studied in association with development and prognosis of various malignancies. However, the potential role of genetic polymorphisms of cancer stem cell (CSC) marker genes with respect to cancer risk has not been examined. We conducted a case-control study involving a total of 1000 subjects (500 lung cancer patients and 500 age-matched cancer-free controls) from northeastern China. Lung cancer risk was analyzed in a logistic regression model in association with genotypes of four lung CSC marker genes (CD133, ALDH1, Musashi-1, and EpCAM). Using univariate analysis, the Musashi-1 rs2522137 GG genotype was found to be associated with a higher incidence of lung cancer compared with the TT genotype. No significant associations were observed for gene variants of CD133, ALDH1, or EpCAM. In multivariate analysis, Musashi-1 rs2522137 was still significantly associated with lung cancer when environmental and lifestyle factors were incorporated in the model, including lower BMI; family history of cancer; prior diagnosis of chronic obstructive pulmonary disease, pneumonia, or pulmonary tuberculosis; occupational exposure to pesticide; occupational exposure to gasoline or diesel fuel; heavier smoking; and exposure to heavy cooking emissions. The value of the area under the receiver-operating characteristic (ROC) curve (AUC) was 0.7686. To our knowledge, this is the first report to show an association between a Musashi-1 genotype and lung cancer risk. Further, the prediction model in this study may be useful in determining individuals with high risk of lung cancer.
publisher	Public Library of Science
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008537/
_version_	1612084855156244480

Cancer Stem Cell Marker Musashi-1 rs2522137 Genotype Is Associated with an Increased Risk of Lung Cancer

Similar Items