Multistep tumorigenesis and the microenvironment
Early-stage cancers have long been considered to be less aggressive than late-stage cancers because it is assumed that they have accumulated fewer of the mutations that are required for full metastatic potential. For breast cancer, recent gene expression profiling data have challenged this paradigm...
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| Format: | Online |
| Language: | English |
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BioMed Central
2004
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC400664/ |
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pubmed-400664 |
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pubmed-4006642004-05-01 Multistep tumorigenesis and the microenvironment Schedin, Pepper Elias, Anthony Review Early-stage cancers have long been considered to be less aggressive than late-stage cancers because it is assumed that they have accumulated fewer of the mutations that are required for full metastatic potential. For breast cancer, recent gene expression profiling data have challenged this paradigm by identifying early-stage cancers with similar gene expression profiles to fully metastatic cancers. In this review, multistep carcinogenesis is reconsidered in light of these new data. The concept that the tumor stroma plays a key role in determining whether a metastatic tumor cell will remain dormant or become invasive is discussed. Recent studies demonstrating the feasibility of targeting tumor stroma for cancer prevention and treatment are presented. BioMed Central 2004 2004-02-12 /pmc/articles/PMC400664/ /pubmed/14979914 Text en Copyright © 2004 BioMed Central Ltd |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Schedin, Pepper Elias, Anthony |
| spellingShingle |
Schedin, Pepper Elias, Anthony Multistep tumorigenesis and the microenvironment |
| author_facet |
Schedin, Pepper Elias, Anthony |
| author_sort |
Schedin, Pepper |
| title |
Multistep tumorigenesis and the microenvironment |
| title_short |
Multistep tumorigenesis and the microenvironment |
| title_full |
Multistep tumorigenesis and the microenvironment |
| title_fullStr |
Multistep tumorigenesis and the microenvironment |
| title_full_unstemmed |
Multistep tumorigenesis and the microenvironment |
| title_sort |
multistep tumorigenesis and the microenvironment |
| description |
Early-stage cancers have long been considered to be less aggressive than late-stage cancers because it is assumed that they have accumulated fewer of the mutations that are required for full metastatic potential. For breast cancer, recent gene expression profiling data have challenged this paradigm by identifying early-stage cancers with similar gene expression profiles to fully metastatic cancers. In this review, multistep carcinogenesis is reconsidered in light of these new data. The concept that the tumor stroma plays a key role in determining whether a metastatic tumor cell will remain dormant or become invasive is discussed. Recent studies demonstrating the feasibility of targeting tumor stroma for cancer prevention and treatment are presented. |
| publisher |
BioMed Central |
| publishDate |
2004 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC400664/ |
| _version_ |
1611368392410791936 |