Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding

Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding

Retroviruses favor target-DNA (tDNA) distortion and particular bases at sites of integration, but the mechanism underlying HIV-1 selectivity is unknown. Crystal structures revealed a network of prototype foamy virus (PFV) integrase residues that distort tDNA: Ala188 and Arg329 interact with tDNA bas...

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Bibliographic Details
Main Authors: Serrao, Erik, Krishnan, Lavanya, Shun, Ming-Chieh, Li, Xiang, Cherepanov, Peter, Engelman, Alan, Maertens, Goedele N.
Format: Online
Language:English
Published: Oxford University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005685/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005685/

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