Effects of 14 frequently used drugs on prostate-specific antigen expression in prostate cancer LNCaP cells

Prostate cancer occurs more frequently among older males and such elderly individuals often have chronic underlying disorders for which various drugs are administered for treatment. The levels of prostate-specific antigen (PSA), a widely used prostate cancer marker, are influenced by a number of dru...

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Main Authors:	IGUCHI, KAZUHIRO, HASHIMOTO, MAKI, KUBOTA, MASAFUMI, YAMASHITA, SHUJI, NAKAMURA, MITSUHIRO, USUI, SHIGEYUKI, SUGIYAMA, TADASHI, HIRANO, KAZUYUKI
Format:	Online
Language:	English
Published:	D.A. Spandidos 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997723/

id	pubmed-3997723
recordtype	oai_dc
spelling	pubmed-39977232014-04-24 Effects of 14 frequently used drugs on prostate-specific antigen expression in prostate cancer LNCaP cells IGUCHI, KAZUHIRO HASHIMOTO, MAKI KUBOTA, MASAFUMI YAMASHITA, SHUJI NAKAMURA, MITSUHIRO USUI, SHIGEYUKI SUGIYAMA, TADASHI HIRANO, KAZUYUKI Articles Prostate cancer occurs more frequently among older males and such elderly individuals often have chronic underlying disorders for which various drugs are administered for treatment. The levels of prostate-specific antigen (PSA), a widely used prostate cancer marker, are influenced by a number of drugs, such as non-steroidal anti-inflammatory drugs and statins. In the present study, the drugs prescribed to patients on a repeat prescription collected at the pharmacy of the Gifu Pharmaceutical University (Gifu, Japan) were examined for their effects on the levels of PSA expression in prostate cancer LNCaP cells. Among the 14 drugs investigated, betamethasone, an agonist of the glucocorticoid receptor, was found to increase the levels of PSA mRNA expression in the LNCaP cells. This betamethasone-induced expression was mediated, at least in part, through androgen receptor (AR) transcriptional activation. Dexamethasone, a typical agonist of the glucocorticoid receptor, was also found to stimulate the AR transcriptional activity, however, to a lesser extent than betamethasone. Therefore, it would be interesting to examine in future studies whether the serum PSA levels in prostate cancer patients are influenced by betamethasone. D.A. Spandidos 2014-05 2014-03-05 /pmc/articles/PMC3997723/ /pubmed/24765197 http://dx.doi.org/10.3892/ol.2014.1936 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	IGUCHI, KAZUHIRO HASHIMOTO, MAKI KUBOTA, MASAFUMI YAMASHITA, SHUJI NAKAMURA, MITSUHIRO USUI, SHIGEYUKI SUGIYAMA, TADASHI HIRANO, KAZUYUKI
spellingShingle	IGUCHI, KAZUHIRO HASHIMOTO, MAKI KUBOTA, MASAFUMI YAMASHITA, SHUJI NAKAMURA, MITSUHIRO USUI, SHIGEYUKI SUGIYAMA, TADASHI HIRANO, KAZUYUKI Effects of 14 frequently used drugs on prostate-specific antigen expression in prostate cancer LNCaP cells
author_facet	IGUCHI, KAZUHIRO HASHIMOTO, MAKI KUBOTA, MASAFUMI YAMASHITA, SHUJI NAKAMURA, MITSUHIRO USUI, SHIGEYUKI SUGIYAMA, TADASHI HIRANO, KAZUYUKI
author_sort	IGUCHI, KAZUHIRO
title	Effects of 14 frequently used drugs on prostate-specific antigen expression in prostate cancer LNCaP cells
title_short	Effects of 14 frequently used drugs on prostate-specific antigen expression in prostate cancer LNCaP cells
title_full	Effects of 14 frequently used drugs on prostate-specific antigen expression in prostate cancer LNCaP cells
title_fullStr	Effects of 14 frequently used drugs on prostate-specific antigen expression in prostate cancer LNCaP cells
title_full_unstemmed	Effects of 14 frequently used drugs on prostate-specific antigen expression in prostate cancer LNCaP cells
title_sort	effects of 14 frequently used drugs on prostate-specific antigen expression in prostate cancer lncap cells
description	Prostate cancer occurs more frequently among older males and such elderly individuals often have chronic underlying disorders for which various drugs are administered for treatment. The levels of prostate-specific antigen (PSA), a widely used prostate cancer marker, are influenced by a number of drugs, such as non-steroidal anti-inflammatory drugs and statins. In the present study, the drugs prescribed to patients on a repeat prescription collected at the pharmacy of the Gifu Pharmaceutical University (Gifu, Japan) were examined for their effects on the levels of PSA expression in prostate cancer LNCaP cells. Among the 14 drugs investigated, betamethasone, an agonist of the glucocorticoid receptor, was found to increase the levels of PSA mRNA expression in the LNCaP cells. This betamethasone-induced expression was mediated, at least in part, through androgen receptor (AR) transcriptional activation. Dexamethasone, a typical agonist of the glucocorticoid receptor, was also found to stimulate the AR transcriptional activity, however, to a lesser extent than betamethasone. Therefore, it would be interesting to examine in future studies whether the serum PSA levels in prostate cancer patients are influenced by betamethasone.
publisher	D.A. Spandidos
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997723/
_version_	1612081701604818944

Effects of 14 frequently used drugs on prostate-specific antigen expression in prostate cancer LNCaP cells

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