Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication

Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication

The ability of PRC1 and PRC2 to promote proliferation is a main feature that links polycomb (PcG) activity to cancer. PcGs silence the expression of the tumour suppressor locus Ink4a/Arf, whose products positively regulate pRb and p53 functions. Enhanced PcG activity is a frequent feature of human t...

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Bibliographic Details
Main Authors: Piunti, Andrea, Rossi, Alessandra, Cerutti, Aurora, Albert, Mareike, Jammula, Sriganesh, Scelfo, Andrea, Cedrone, Laura, Fragola, Giulia, Olsson, Linda, Koseki, Haruhiko, Testa, Giuseppe, Casola, Stefano, Helin, Kristian, di Fagagna, Fabrizio d’Adda, Pasini, Diego
Format: Online
Language:English
Published: Nature Pub. Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996544/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996544/

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