Small molecule inhibition of CBP/catenin interactions eliminates drug resistant clones in acute lymphoblastic leukemia

Small molecule inhibition of CBP/catenin interactions eliminates drug resistant clones in acute lymphoblastic leukemia

Drug resistance in acute lymphoblastic leukemia (ALL) remains a major problem warranting new treatment strategies. Wnt/catenin signaling is critical for the self-renewal of normal hematopoietic progenitor cells. Deregulated Wnt signaling is evident in chronic and acute myeloid leukemia, however litt...

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Bibliographic Details
Main Authors: Gang, Eun Ji, Hsieh, Yao-Te, Pham, Jennifer, Zhao, Yi, Nguyen, Cu, Huantes, Sandra, Park, Eugene, Naing, Khatija, Klemm, Lars, Swaminathan, Srividya, Conway, Edward M., Pelus, Louis M., Crispino, John, Mullighan, Charles, McMillan, Michael, Müschen, Markus, Kahn, Michael, Kim, Yong-Mi
Format: Online
Language:English
Published: 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994178/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994178/

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