Role of Glycogen Synthase Kinase-3β in APP Hyperphosphorylation Induced by NMDA Stimulation in Cortical Neurons

Role of Glycogen Synthase Kinase-3β in APP Hyperphosphorylation Induced by NMDA Stimulation in Cortical Neurons

The phosphorylation of Amyloid Precursor Protein (APP) at Thr668 plays a key role in APP metabolism that is highly relevant to AD. The c-Jun-N-terminal kinase (JNK), glycogen synthase kinase-3β (GSK-3β) and cyclin-dependent kinase 5 (Cdk5) can all be responsible for this phosphorylation. These kinas...

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Bibliographic Details
Main Authors: Ploia, Cristina, Sclip, Alessandra, Colombo, Alessio, Repici, Mariaelena, Gardoni, Fabrizio, Luca, Monica Di, Forloni, Gianluigi, Antoniou, Xanthi, Borsello, Tiziana
Format: Online
Language:English
Published: Molecular Diversity Preservation International 2010
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991020/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991020/

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