Research progress on surface antigen 1 (SAG1) of Toxoplasma gondii
Toxoplasma gondii is an obligate intracellular parasitic protozoan that has a wide host range and causes a zoonotic parasitosis called toxoplasmosis. This infection causes significant morbidity, costs for care and loss of productivity and suffering. The most effective measures to minimize this paras...
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BioMed Central
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989796/ |
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pubmed-39897962014-04-18 Research progress on surface antigen 1 (SAG1) of Toxoplasma gondii Wang, Yanhua Yin, Hong Review Toxoplasma gondii is an obligate intracellular parasitic protozoan that has a wide host range and causes a zoonotic parasitosis called toxoplasmosis. This infection causes significant morbidity, costs for care and loss of productivity and suffering. The most effective measures to minimize this parasite’s harm to patients are prompt diagnosis and treatment and preventing infection. A parasite surface antigen, SAG1, is considered an important antigen for the development of effective diagnostic tests or subunit vaccines. This review covers several aspects of this antigen, including its gene structure, contribution to host invasion, mechanisms of the immune responses and its applications for diagnosis and vaccine development. This significant progress on this antigen provides foundations for further development of more effective and precise approaches to diagnose toxoplasmosis in the clinic, and also have important implications for exploring novel measures to control toxoplasmosis in the near future. BioMed Central 2014-04-13 /pmc/articles/PMC3989796/ /pubmed/24726014 http://dx.doi.org/10.1186/1756-3305-7-180 Text en Copyright © 2014 Wang and Yin; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Wang, Yanhua Yin, Hong |
| spellingShingle |
Wang, Yanhua Yin, Hong Research progress on surface antigen 1 (SAG1) of Toxoplasma gondii |
| author_facet |
Wang, Yanhua Yin, Hong |
| author_sort |
Wang, Yanhua |
| title |
Research progress on surface antigen 1 (SAG1) of Toxoplasma gondii |
| title_short |
Research progress on surface antigen 1 (SAG1) of Toxoplasma gondii |
| title_full |
Research progress on surface antigen 1 (SAG1) of Toxoplasma gondii |
| title_fullStr |
Research progress on surface antigen 1 (SAG1) of Toxoplasma gondii |
| title_full_unstemmed |
Research progress on surface antigen 1 (SAG1) of Toxoplasma gondii |
| title_sort |
research progress on surface antigen 1 (sag1) of toxoplasma gondii |
| description |
Toxoplasma gondii is an obligate intracellular parasitic protozoan that has a wide host range and causes a zoonotic parasitosis called toxoplasmosis. This infection causes significant morbidity, costs for care and loss of productivity and suffering. The most effective measures to minimize this parasite’s harm to patients are prompt diagnosis and treatment and preventing infection. A parasite surface antigen, SAG1, is considered an important antigen for the development of effective diagnostic tests or subunit vaccines. This review covers several aspects of this antigen, including its gene structure, contribution to host invasion, mechanisms of the immune responses and its applications for diagnosis and vaccine development. This significant progress on this antigen provides foundations for further development of more effective and precise approaches to diagnose toxoplasmosis in the clinic, and also have important implications for exploring novel measures to control toxoplasmosis in the near future. |
| publisher |
BioMed Central |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989796/ |
| _version_ |
1612079130666336256 |