Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery☆
•We now have metabolic network models; the metabolome is represented by their nodes.•Metabolite levels are sensitive to changes in enzyme activities.•Drugs hitchhike on metabolite transporters to get into and out of cells.•The consensus network Recon2 represents the present state of the art, and has...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
Elsevier Science Ltd., Distributed by Virgin Mailing and Distribution
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989035/ |